Astros vs. Mariners: MLB Prediction & Analysis

Our detailed prediction and analysis for the Astros vs. Mariners MLB game on Tuesday, September 22, 2026 is featured below. Drawing from 10,000 game simulations, we provide expert picks, betting odds, and insights.
FINAL
MLB
FINAL
MLB sport icon
MLB
Astros
Cristian Javier 2-6, 5.31 ERA
7
0
T-Mobile Park
Mariners
Logan Gilbert 12-10, 3.69 ERA
T-Mobile Park
1 2 3 4 5 6 7 8 9 RHE
Astros
1 0 3 0 0 1 0 2 0 7 12 0
Mariners
0 0 0 0 0 0 0 0 0 0 4 1
Live Probabilities
Win %
  • Astros
    100%
  • Mariners
    0%
Win Probability
Baseball infield diamond diagram
Last At Bat
Outs
Michael Arroyo strikes out swinging.
Quick Box Score
Astros Hitting
No.PlayerPosABRHRBIHRBBSOAVGOPS
1 N. Allen SS0000000.0000.000
2 Y. Alvarez DH4123100.5001.850
3 I. Paredes 3B4121110.5001.850
4 J. Altuve 2B5120002.4000.800
5 Y. Diaz C5120001.4000.800
6 C. Walker 1B5113101.2001.000
7 T. Trammell CF3000020.0000.400
8 C. Smith RF5010001.2000.600
9 N. Velázquez LF1000000.0000.000
Mariners Hitting
No.PlayerPosABRHRBIHRBBSOAVGOPS
1 J. Crawford 3B3000010.0000.250
2 R. Arozarena LF1000021.0000.750
3 D. Canzone DH4010001.2500.500
4 C. Raleigh C3000010.0000.250
5 J. Rodríguez CF4020000.5001.000
6 J. Naylor 1B4000001.0000.000
7 C. Young SS3010012.3330.833
8 L. Montes RF4000002.0000.000
9 M. Arroyo 2B2000001.0000.000

Astros vs. Mariners: Detailed Breakdown

Matchup overview: MLB Tuesday

  • Teams: Houston Astros vs. Seattle Mariners
  • Date: Tuesday, September 22, 2026
  • Time: 9:40PM ET
  • Venue: T-Mobile Park

Current betting odds

  • Spread: Astros (+1.5, -170), Mariners (-1.5, +174)
  • Moneyline: Astros +122, Mariners -125
  • Total (Over/Under): 7.5 runs (+117/-117)

Dimers’ win probabilities

  • Astros: 42.2%
  • Mariners: 57.8%

Dimers' predictive MLB model, renowned for its accuracy, assesses each team's chances by simulating the outcome of the game 10,000 times. This method provides a precise and unbiased view.

Our Prediction: Who Wins?

After extensive simulations, our model gives the Astros a win probability of 42.2%, while the Mariners have a win probability of 57.8%.

Summary

According to our analysis, the Mariners are more likely to beat the Astros in the MLB game at T-Mobile Park on Tuesday. Discover the best run line, over/under and moneyline odds, picks and probabilities for the game on this page.

Our Astros vs. Mariners predictions, based on sophisticated simulations and current data, guide you in making informed decisions. Remember to bet responsibly and within your financial limits.

For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

When you click or tap on a link on Dimers that goes to a third-party website that we have a commercial relationship with (such as a sportsbook), we may receive a referral fee.

For further insights, explore our expert MLB predictions and the best MLB bets today, while our in-depth analysis includes MLB props, MLB futures, MLB odds, and the latest MLB news.