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Read Article Pirates vs. Brewers prediction: Why Milwaukee is favored to win Wednesday's MLB matchup [8/5/2026]
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Written by Dave Garofolo, Content Producer
Get Pittsburgh Pirates vs Milwaukee Brewers predictions for MLB Wednesday.
The Milwaukee Brewers will take on the Pittsburgh Pirates, in what is expected to be a tight MLB game, at American Family Field on Wednesday, starting at 7:40 PM ET.
The Brewers will send Kyle Harrison (8-2, 3.01 ERA) to the mound, up against Paul Skenes (9-9, 3.90 ERA) for the Pirates.
Dimers' advanced MLB model gives the Brewers a slight edge with a 52.1% win probability over the Pirates.
This article offers a closer look at Wednesday's Pirates vs. Brewers matchup, including best bets and picks.
Pirates vs. Brewers prediction: Who will win and cover?
Using innovative machine learning and data, we have simulated the outcome of Wednesday's MLB game between the Pirates and Brewers, forming part of our MLB predictions coverage.
Our leading predictive model currently gives the Brewers a 52.1% chance of defeating the Pirates.
According to our model, the Pirates (+1.5) have a 65.4% chance of covering the run line, while the 6.5-run over/under has a 60.6% chance of going over,.
Pirates vs. Brewers odds [8/5/2026]
We have sourced the best MLB odds in America for this game, which are listed here:
| Bet Type | Pirates | Brewers |
|---|---|---|
| Run Line | +1.5 (-186) | -1.5 (+180) |
| Moneyline | +123 | -122 |
| Total | o6.5 (-127) | u6.5 (+122) |
All odds are correct at the time of publication and are subject to change.
Pirates vs. Brewers picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Pirates +1.5 | -186 |
| Moneyline | Pirates | +123 |
| Total | Over 6.5 | -127 |
According to our MLB best bets, the top play to make on this game is Over 6.5 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Pirates vs. Brewers game-day updates and essential details
Wednesday's MLB matchup between the Brewers and Pirates at American Family Field is scheduled to start at 7:40 PM ET.
- Who: Pittsburgh Pirates vs. Milwaukee Brewers
- Date: Wednesday, August 5, 2026
- Time: 7:40 PM ET/4:40PM PT
- Venue: American Family Field
Conclusion
We predict the Brewers, with a 52.1% win probability, will likely beat the Pirates in Wednesday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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