MLB picks today: Tuesday's MLB best bets include Red Sox vs. Yankees play [9/29/2026]

Red Sox vs. Yankees Over 6.5 runs (+113)

• Edge: 10.8%
• Probability: 57.7%
• Matchup: Red Sox vs. Yankees (8:00PM ET)

Our model has identified value on Over 6.5 runs in Red Sox vs. Yankees at 47¢ odds. A 57.7% probability produces an edge of 10.8%, making this the strongest play for today's MLB slate.

Astros -1.5 (+170)

• Edge: 5.7%
• Probability: 42.7%
• Matchup: White Sox vs. Astros (5:00PM ET)

Astros -1.5 carries a 5.7% edge and a probability of 42.7% at 37¢ odds, according to our model.

Phillies vs. Braves Over 6.5 runs (-113)

• Edge: 4.3%
• Probability: 57.3%
• Matchup: Phillies vs. Braves (2:00PM ET)

Phillies vs. Braves Over 6.5 runs at 53¢ odds shows a 4.3% edge, supported by a 57.3% probability in simulations.

Astros ML (-117)

• Edge: 3.8%
• Probability: 57.7%
• Matchup: White Sox vs. Astros (5:00PM ET)

A 3.8% edge and 57.7% probability makes Astros at the moneyline a value play in the White Sox vs. Astros matchup, per our model.

Yankees -1.5 (+178)

• Edge: 3.7%
• Probability: 39.6%
• Matchup: Red Sox vs. Yankees (8:00PM ET)

Yankees -1.5 at 36¢ presents a 3.7% edge, with simulations resulting in a probability of 39.6%.

Braves -1.5 (+135)

• Edge: 3.4%
• Probability: 46%
• Matchup: Phillies vs. Braves (2:00PM ET)

Our model finds value on Braves -1.5 at 43¢, supported by an edge of 3.4%.

White Sox vs. Astros Over 8.5 runs (+113)

• Edge: 3.4%
• Probability: 50.3%
• Matchup: White Sox vs. Astros (5:00PM ET)

Our model has uncovered value on White Sox vs. Astros Over 8.5 runs at 47¢. A 50.3% probability produces a 3.4% edge, making this a strong play for today's MLB action.

Cubs vs. Padres Over 7.5 runs (+117)

• Edge: 3.3%
• Probability: 49.4%
• Matchup: Cubs vs. Padres (10:00PM ET)

A 3.3% edge on a 49.4% probability makes Over 7.5 runs at 46¢a solid value play in today's Cubs vs. Padres matchup.

MLB Playoffs best bets summary: Tuesday, 9/29/2026

As of 1:05AM ET, here are our top MLB bets by edge recommended by our model:

List of upcoming MLB postseason games to bet on [9/29/2026]

• Phillies vs. Braves (2:00PM ET, Tuesday)
• White Sox vs. Astros (5:00PM ET, Tuesday)
• Red Sox vs. Yankees (8:00PM ET, Tuesday)
• Cubs vs. Padres (10:00PM ET, Tuesday)

Conclusion

Our MLB best bets are locked and loaded for September 29, 2026, featuring plays such as over 6.5 runs in the Red Sox vs. Yankees matchup and Astros -1.5. Powered by advanced simulations, these picks are here to boost your betting game.

Our predictions are rooted in current data to help you make informed decisions. For additional resources and advice, head to our Responsible Gambling hub.

All odds and probabilities in this article are correct and accurate at the time of publication.