Cubs vs. Cardinals prediction: Cubs favored to win Wednesday's MLB matchup [7/29/2026]
Get Chicago Cubs vs St. Louis Cardinals predictions for MLB Wednesday.
The St. Louis Cardinals and Chicago Cubs are scheduled to meet in MLB action at Busch Stadium on Wednesday, starting at 7:45 PM ET.
The Cardinals will start Dustin May (5-7, 4.59 ERA), up against Matthew Boyd (6-1, 3.81 ERA) for the Cubs.
Dimers' proven MLB model gives the Cubs a slight edge with a 50.8% win probability over the Cardinals.
This article offers an expanded analysis of Wednesday's Cubs vs. Cardinals matchup, including best bets and picks.
Cubs vs. Cardinals prediction: Who will win and cover?
Our independent predictive model gives the Cubs a 50.8% chance of defeating the Cardinals.
According to our model, the Cardinals (+1.5) have a 61.0% chance of covering the run line, while the over/under total of 7.5 runs has a 55.3% chance of going over,.
Cubs vs. Cardinals odds [7/29/2026]
We have sourced the best MLB odds in America for this game, which are listed here:
| Bet Type | Cubs | Cardinals |
|---|---|---|
| Run Line | -1.5 (+163) | +1.5 (-170) |
| Moneyline | +100 | -102 |
| Total | o7.5 (-108) | u7.5 (+104) |
All odds are correct at the time of publication and are subject to change.
Cubs vs. Cardinals picks and best bet
After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Cubs -1.5 | +163 |
| Moneyline | Cubs | +100 |
| Total | Over 7.5 | -108 |
According to our MLB best bets, the top play to make on this game is Over 7.5 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Cubs vs. Cardinals game-day updates and essential details
Wednesday's MLB game between the Cardinals and Cubs at Busch Stadium is scheduled to begin at 7:45 PM ET.
- Who: Chicago Cubs vs. St. Louis Cardinals
- Date: Wednesday, July 29, 2026
- Time: 7:45 PM ET/4:45PM PT
- Venue: Busch Stadium
Conclusion
We predict the Cubs, with a 50.8% win probability, will likely beat the Cardinals in Wednesday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
