Sep 20, 2026
Nationals vs. Cardinals prediction: St. Louis favored to win Sunday's MLB matchup [9/20/2026]
Read Article Cubs vs. Reds prediction: Why Cubs are favored to win Sunday's MLB matchup [9/20/2026]
Updated: | First published:
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Written by Dave Garofolo, Content Producer
Dimers' simulation model projects a 56.5% win probability for the Cubs at Great American Ball Park.
The Cincinnati Reds will face the Chicago Cubs in MLB action at Great American Ball Park on Sunday, beginning at 1:40 PM ET.
Rhett Lowder (6-11, 5.79 ERA) will be the starting pitcher for the Reds, while the Cubs will counter with David Peterson (8-8, 5.11 ERA).
Dimers' advanced MLB model projects the Cubs as the most likely winner in this Cubs vs. Reds prediction.
This article offers a closer look at Sunday's matchup, including best bets and picks.
Cubs vs. Reds prediction and odds
Using innovative machine learning and data analysis, we have re-simulated the outcome of Sunday's MLB game between the Cubs and Reds, forming part of our MLB predictions coverage.
Our famous predictive model currently gives the Cubs a 56.5% chance of defeating the Reds. According to our model, the Reds (+1.5) have a 55.0% chance of covering the run line, while the over/under total of 9.5 runs has a 53.3% chance of going over.
Latest betting odds
We have sourced the best MLB odds in America for this game, which are listed here:
- Run Line: Cubs -1.5 (+111) / Reds +1.5 (-115)
- Moneyline: Cubs -150, Reds +150
- Total: Over/Under 9.5 (-113/+102)
All odds are correct at the time of publication and are subject to change.
Model picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:
- Run line: Reds +1.5 @ 53¢ via Novig
- Moneyline: Reds @ 40¢ via Polymarket
- Total: Over 9.5 @ 53¢ via Polymarket
According to our MLB best bets, the top play to make on this game is Reds to win.
These picks are based on our probabilities matched against the implied probabilities from the current available odds.
Game info & first pitch details
Sunday's MLB matchup between the Reds and Cubs at Great American Ball Park is scheduled to commence at 1:40 PM ET.
- Who: Chicago Cubs vs. Cincinnati Reds
- Date: Sunday, September 20, 2026
- Time: 1:40 PM ET/10:40AM PT
- Venue: Great American Ball Park
Conclusion
We predict the Cubs, with a 56.5% win probability, will likely beat the Reds in Sunday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
This article's predictions and probabilities are generated by Dimers' proprietary MLB prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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