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Read Article Athletics vs. Reds prediction: Why Cincinnati is favored to win Wednesday's MLB matchup [8/5/2026]
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Written by Dave Garofolo, Content Producer
Get Athletics vs Cincinnati Reds predictions for MLB Wednesday.
The Cincinnati Reds will take on the Athletics in MLB action at Great American Ball Park on Wednesday, starting at 6:40 PM ET.
The Reds will start Rhett Lowder (3-7, 5.42 ERA), while the Athletics have opted for Jacob Lopez (5-4, 5.79 ERA).
Dimers' advanced MLB model projects the Reds as the most likely winner in this Athletics vs. Reds prediction.
This article offers an expanded analysis of Wednesday's matchup, including best bets and picks.
A's vs. Reds prediction: Who will win and cover?
Using powerful machine learning and data, we have simulated the outcome of Wednesday's MLB matchup between the Athletics and Reds, forming part of our MLB predictions coverage.
Our famous predictive model gives the Reds a 57.6% chance of defeating the Athletics.
According to our model, the Athletics (+1.5) have a 59.4% chance of covering the run line, while the over/under total of 9.5 runs has a 54.6% chance of going over,.
Athletics vs. Reds odds [8/5/2026]
We have sourced the best MLB odds in America for this game, which are listed here:
| Bet Type | Athletics | Reds |
|---|---|---|
| Run Line | +1.5 (-135) | -1.5 (+133) |
| Moneyline | +154 | -150 |
| Total | o9.5 (+108) | u9.5 (-105) |
All odds are correct at the time of publication and are subject to change.
Athletics vs. Reds picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Athletics +1.5 | -135 |
| Moneyline | Athletics | +154 |
| Total | Over 9.5 | +108 |
According to our best MLB bets, the top play to make on this game is Over 9.5 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
A's vs. Reds game-day updates and essential details
Wednesday's MLB action between the Reds and Athletics at Great American Ball Park is scheduled to start at 6:40 PM ET.
- Who: Athletics vs. Cincinnati Reds
- Date: Wednesday, August 5, 2026
- Time: 6:40 PM ET/3:40PM PT
- Venue: Great American Ball Park
Conclusion
We predict the Reds, with a 57.6% win probability, will likely beat the Athletics in Wednesday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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