Ohio State vs. Nebraska: College Football Week 12 Prediction, Picks & Odds
Spread
- Ohio State
- Nebraska
Ohio State vs. Nebraska: Detailed Breakdown
Matchup overview: College Football Week 12
- Teams: Ohio State vs. Nebraska
- Date: Saturday, November 21, 2026
- Time: 12:00PM ET
- Venue: Memorial Stadium (Lincoln, NE)
Current betting odds
- Spread: Ohio State (-5.5, -110), Nebraska (+5.5, -110)
- Moneyline: Ohio State -176, Nebraska +164
- Total (Over/Under): 43.5 points (-110/-110)
Dimers’ win probabilities
- Ohio State: 61.6%
- Nebraska: 38.4%
These probabilities come from two machine learning models that assess more than 100 data points for each college football matchup, combining their outputs to project all our major betting markets.
Projected final score
Our predicted final score for this college football matchup is Ohio State 25-21 Nebraska.
This prediction draws on each team's scoring trends and player stats, weighed across both of our data models
Our Prediction: Who Wins?
The numbers give the Ohio State a win probability of 61.6%, while the Nebraska have a win probability of 38.4%.
Summary
Ohio State faces off against Nebraska in college football action at Memorial Stadium (Lincoln, NE) on Saturday, November 21, 2026.
Our Ohio State vs. Nebraska predictions, built on real-time data and matchup-specific modeling, help guide your decisions. Remember to bet responsibly and within your financial limits.
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For further insights, explore our expert college football predictions and the best college football bets today, while our in-depth analysis includes college football props, college football futures, college football odds, and the latest college football news.