San Diego vs. Cal Poly prediction: Why Cal Poly is favored to win in college football Week 3 [2026]

Using powerful machine learning and data, we have re-simulated the outcome of San Diego vs. Cal Poly, forming part of our college football predictions coverage.

Our independent predictive model currently gives Cal Poly a 92.2% chance of beating San Diego. Our predicted final score has Cal Poly winning 38-19. According to our model, Cal Poly (-18.5) has a 51.1% chance of covering the spread, while the 58.5-point over/under has a 51.2% chance of staying under.

Latest betting odds

We have sourced the best college football odds in America for this game, which are listed here:

• Spread: San Diego +18.5 (-110) / Cal Poly -18.5 (-110)
• Moneyline: San Diego +800, Cal Poly -1300
• Total: Over/Under 58.5 (+100/-118)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Cal Poly -18.5 @ -110 via bet365
• Moneyline: Cal Poly @ -1300 via bet365
• Total: Over 58.5 @ +100 via bet365

According to our best college football bets, the top play to make on this game is Cal Poly to win.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football game between Cal Poly and San Diego at Mustang Memorial Field is scheduled to start at 8:00 PM ET.

• Who: San Diego vs. Cal Poly
• Date: Saturday, September 19, 2026
• Time: 8:00 PM ET/5:00PM PT
• Venue: Mustang Memorial Field

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Conclusion

We predict Cal Poly, with a 92.2% win probability, will likely beat San Diego in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.