Ohio vs. South Alabama prediction favors South Alabama to win in college football Week 3 [2026]

Using trusted machine learning and data, we have re-simulated the outcome of Ohio vs. South Alabama, forming part of our college football predictions coverage.

Our famous predictive model currently gives South Alabama a 69.3% chance of defeating Ohio. Our predicted final score has South Alabama winning 28-22. According to our model, South Alabama (-6.5) has a 51.9% chance of covering the spread, while the over/under total of 48.5 points has a 56.0% chance of going over.

Latest betting odds

We have sourced the best college football odds in America for this game, which are listed here:

• Spread: Ohio +6.5 (-105) / South Alabama -6.5 (-115)
• Moneyline: Ohio +220, South Alabama -245
• Total: Over/Under 48.5 (-117/-108)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: South Alabama -6.5 @ -115 via FanDuel
• Moneyline: Ohio @ +220 via bet365
• Total: Over 48.5 @ -117 via BetRivers

According to our best college football bets, the top play to make on this game is Over 48.5 total points.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football game between South Alabama and Ohio at Hancock Whitney Stadium is scheduled to commence at 7:00 PM ET.

• Who: Ohio vs. South Alabama
• Date: Saturday, September 19, 2026
• Time: 7:00 PM ET/4:00PM PT
• Venue: Hancock Whitney Stadium

College football Week 3 promos

Make the most of Dimers' Ohio vs. South Alabama predictions by exploring the Underdog Fantasy offer below:

Plus, check out the latest details on the current offer from Polymarket.

Conclusion

We predict South Alabama, with a 69.3% win probability, will likely beat Ohio in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.