Mississippi Valley State vs. Texas Southern prediction: Why Texas Southern is favored to win in college football Week 6 [2026]

Using trusted machine learning and data analysis, we have re-simulated the result of Mississippi Valley State vs. Texas Southern, forming part of our college football predictions coverage.

Our leading predictive model gives Texas Southern an 86.2% chance of defeating Mississippi Valley State. Our predicted final score has Texas Southern winning 35-20. According to our model, Texas Southern (-14) has a 52.0% chance of covering the spread, while the over/under total of 56.5 points has a 50.2% chance of going over.

Latest betting odds

We have researched the best college football odds in America for this game, which are listed here:

• Spread: Mississippi Valley State +14 (-121) / Texas Southern -14 (+100)
• Moneyline: Mississippi Valley State +435, Texas Southern -600
• Total: Over/Under 56.5 (+100/-123)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Texas Southern -14 @ +100 via bet365
• Moneyline: Texas Southern @ -600 via bet365
• Total: Over 56.5 @ +100 via bet365

According to our college football best bets, the top play to make on this game is Texas Southern -14 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football matchup between Texas Southern and Mississippi Valley State at W.W. Thorne Stadium is scheduled to begin at 3:00 PM ET.

• Who: Mississippi Valley State vs. Texas Southern
• Date: Saturday, October 10, 2026
• Time: 3:00 PM ET/12:00PM PT
• Venue: W.W. Thorne Stadium

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Conclusion

We predict Texas Southern, with an 86.2% win probability, will likely beat Mississippi Valley State in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.