Mississippi State vs. South Carolina prediction favors South Carolina to win in college football Week 3 [2026]

Using trusted machine learning and statistical analysis, we have re-simulated the result of Mississippi State vs. South Carolina, forming part of our college football predictions coverage.

Our independent predictive model currently gives South Carolina a 65.4% chance of beating Mississippi State. Our predicted final score has South Carolina winning 31-26. According to our model, South Carolina (-4) has a 51.9% chance of covering the spread, while the over/under total of 58.5 points has a 51.4% chance of staying under.

Latest betting odds

We have sourced the best college football odds in America for this game, which are listed here:

• Spread: Mississippi State +4 (-113) / South Carolina -4 (-108)
• Moneyline: Mississippi State +155, South Carolina -179
• Total: Over/Under 58.5 (-110/-108)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: South Carolina -4 @ -108 via Caesars
• Moneyline: South Carolina @ -179 via Caesars
• Total: Under 58.5 @ -108 via DraftKings

According to our college football best bets, the top play to make on this game is South Carolina to win.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football game between South Carolina and Mississippi State at Williams-Brice Stadium is scheduled to begin at 4:15 PM ET.

• Who: Mississippi State vs. South Carolina
• Date: Saturday, September 19, 2026
• Time: 4:15 PM ET/1:15PM PT
• Venue: Williams-Brice Stadium

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Conclusion

We predict South Carolina, with a 65.4% win probability, will likely beat Mississippi State in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.