Illinois State vs. Southern Illinois prediction favors Illinois State to win in college football Week 7 [2026]

Using powerful machine learning and data analysis, we have re-simulated the result of Illinois State vs. Southern Illinois, forming part of our college football predictions coverage.

Our independent predictive model gives Illinois State a 67.6% chance of beating Southern Illinois. Our predicted final score has Illinois State winning 30-24. According to our model, Southern Illinois (+7) has a 52.3% chance of covering the spread, while the 54.5-point over/under has a 50.2% chance of staying under.

Latest betting odds

We have sourced the best college football odds in America for this game, which are listed here:

• Spread: Illinois State -7 (-108) / Southern Illinois +7 (-112)
• Moneyline: Illinois State -212, Southern Illinois +201
• Total: Over/Under 54.5 (+102/-108)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Southern Illinois +7 @ -112 via DraftKings
• Moneyline: Illinois State @ 68¢ via Novig
• Total: Over 54.5 @ 50¢ via Novig

According to our college football best bets, the top play to make on this game is Over 54.5 total points.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football action between Southern Illinois and Illinois State at Saluki Stadium is scheduled to commence at 4:00 PM ET.

• Who: Illinois State vs. Southern Illinois
• Date: Saturday, October 17, 2026
• Time: 4:00 PM ET/1:00PM PT
• Venue: Saluki Stadium

College football Week 7 promos

Make the most of Dimers' Illinois State vs. Southern Illinois predictions by exploring the Bet365 Sportsbook offer below:

In Texas or Oklahoma? Check out this exclusive offer where you can secure $25 in Predictions Dollars as soon as either team scores in today's Sooners-Longhorns clash.

Conclusion

We predict Illinois State, with a 67.6% win probability, will likely beat Southern Illinois in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.