Duquesne vs. Youngstown State prediction favors Youngstown State to win in college football Week 2 [2026]

Youngstown State and Duquesne will meet in Week 2 college football action at Arnold D. Stambaugh Stadium on Saturday, starting at 2:00 PM ET.

Dimers' advanced college football model gives Youngstown State a slight edge with a 94.9% win probability over Duquesne.

This article offers a complete Duquesne vs. Youngstown State prediction, including an expanded look at the predicted score, best bets and picks, backed by the same system that has dominated college football and NFL betting markets across multiple seasons.

Duquesne vs. Youngstown State prediction and odds

Using powerful machine learning and data analysis, we have re-simulated the result of Duquesne vs. Youngstown State, forming part of our college football predictions coverage.

Our leading predictive model gives Youngstown State a 94.9% chance of defeating Duquesne. Our predicted final score has Youngstown State winning 39-15. According to our model, Youngstown State (-22.5) has a 52.5% chance of covering the spread, while the 54.5-point over/under has a 51.3% chance of going over.

Latest betting odds

We have sourced the best college football odds in America for this game, which are listed here:

• Spread: Duquesne +22.5 (-109) / Youngstown State -22.5 (-113)
• Moneyline: Duquesne +980, Youngstown State -1700
• Total: Over/Under 54.5 (-110/-104)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Youngstown State -22.5 @ -113 via Caesars
• Moneyline: Youngstown State @ -1700 via bet365
• Total: Over 54.5 @ -110 via DraftKings

According to our college football best bets, the top play to make on this game is Youngstown State to win.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football matchup between Youngstown State and Duquesne at Arnold D. Stambaugh Stadium is scheduled to begin at 2:00 PM ET.

• Who: Duquesne vs. Youngstown State
• Date: Saturday, September 12, 2026
• Time: 2:00 PM ET/11:00AM PT
• Venue: Arnold D. Stambaugh Stadium

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Conclusion

We predict Youngstown State, with a 94.9% win probability, will likely beat Duquesne in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.