College football picks today: Week 1 Sunday best bets include Texas Southern vs. Prairie View play [9/6/2026]

Texas Southern ML (+360)

• Edge: 10.7%
• Probability: 32.4%
• Matchup: Texas Southern vs. Prairie View (12:00PM ET)

Our model has identified value on Texas Southern to defeat Prairie View at +360 odds. A 32.4% probability produces an edge of 10.7%, making this the strongest play for today's college football slate.

Louisville vs. Mississippi Under 55.5 points (-110)

• Edge: 5.8%
• Probability: 58.2%
• Matchup: Louisville vs. Mississippi (7:30PM ET)

Louisville vs. Mississippi under 55.5 points carries a 5.8% edge and a probability of 58.2% at -110 odds, according to our model.

Texas Southern +10.5 (-107)

• Edge: 4.6%
• Probability: 56.3%
• Matchup: Texas Southern vs. Prairie View (12:00PM ET)

Texas Southern +10.5 vs. Prairie View at -107 odds shows a 4.6% edge, supported by a 56.3% probability in simulations.

Louisville ML (+210)

• Edge: 4.5%
• Probability: 36.8%
• Matchup: Louisville vs. Mississippi (7:30PM ET)

A 4.5% edge and 36.8% probability makes Louisville at the moneyline a value play in the Louisville vs. Mississippi matchup, per our model.

Wisconsin vs. Notre Dame Over 46.5 points (-107)

• Edge: 3.4%
• Probability: 55.1%
• Matchup: Wisconsin vs. Notre Dame (7:30PM ET)

Wisconsin vs. Notre Dame Over 46.5 points at -107 odds presents a 3.4% edge, with simulations resulting in a probability of 55.1%.

Louisville +6.5 (+100)

• Edge: 2.6%
• Probability: 52.6%
• Matchup: Louisville vs. Mississippi (7:30PM ET)

Our model finds value on Louisville +6.5 at +100 odds, supported by an edge of 2.6%.

Washington State vs. Washington Under 51.5 points (-113)

• Edge: 2.5%
• Probability: 55.6%
• Matchup: Washington State vs. Washington (4:00PM ET)

Our model has uncovered value on Washington State vs. Washington Under 51.5 points at -113 odds. A 55.6% probability produces a 2.5% edge, making this a strong play for today's college football action.

NCAAF best bets summary: Sunday, 9/6/2026

As of 1:11AM ET, here are our top college football bets by edge recommended by our model:

List of upcoming college football games to bet on now

• Texas Southern vs. Prairie View (12:00PM ET, Sunday)
• South Carolina State vs. Florida A&M (3:00PM ET, Sunday)
• Washington State vs. Washington (4:00PM ET, Sunday)
• Wisconsin vs. Notre Dame (7:30PM ET, Sunday)
• Louisville vs. Mississippi (7:30PM ET, Sunday)

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College football offer for Week 1

Make the most of the picks in this article—including Texas Southern ML—with the Underdog Fantasy offer below:

Conclusion

Our college football best bets are locked and loaded for September 6, 2026, featuring plays such as Texas Southern ML vs. Prairie View and under 55.5 points in the Louisville vs. Mississippi matchup. Powered by advanced simulations, these picks are here to boost your betting game.

Our predictions are based on current data to help you make informed decisions. For additional resources and advice, head to our Responsible Gambling hub.

All odds and probabilities in this article are correct and accurate at the time of publication.