Louisiana-Lafayette vs. Southern Miss prediction favors Louisiana-Lafayette to win in college football Week 8 [2026]

Using trusted machine learning and data analysis, we have re-simulated the outcome of Louisiana-Lafayette vs. Southern Miss, forming part of our college football predictions coverage.

Our independent predictive model currently gives Louisiana-Lafayette a 76.7% chance of defeating Southern Miss. Our predicted final score has Louisiana-Lafayette winning 31-22. According to our model, Southern Miss (+10.5) has a 55.2% chance of covering the spread, while the over/under total of 52.5 points has a 51.9% chance of going over.

Latest betting odds

We have researched the best college football odds in America for this game, which are listed here:

• Spread: Louisiana-Lafayette -10.5 (+106) / Southern Miss +10.5 (-111)
• Moneyline: Louisiana-Lafayette -355, Southern Miss +335
• Total: Over/Under 52.5 (-102/-104)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Southern Miss +10.5 @ 53¢ via Novig
• Moneyline: Southern Miss @ 23¢ via Novig
• Total: Over 52.5 @ 50¢ via Novig

According to our best college football bets, the top play to make on this game is Southern Miss +10.5 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football game between Southern Miss and Louisiana-Lafayette at M.M. Roberts Stadium is scheduled to commence at 5:00 PM ET.

• Who: Louisiana-Lafayette vs. Southern Miss
• Date: Saturday, October 24, 2026
• Time: 5:00 PM ET/2:00 PM PT
• Venue: M.M. Roberts Stadium

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Conclusion

We predict Louisiana-Lafayette, with a 76.7% win probability, will likely beat Southern Miss in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.