Buffalo vs. Florida International prediction favors Florida International to win in college football Week 2 [2026]

Florida International will take on Buffalo in Week 2 college football action at Pitbull Stadium on Saturday, beginning at 6:00 PM ET.

Dimers' proven college football model projects Florida International as the most likely winner in this Buffalo vs. Florida International prediction.

This article offers a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks, backed by the same system that has dominated college football and NFL betting markets across multiple seasons.

Buffalo vs. Florida International prediction and odds

Using innovative machine learning and statistical analysis, we have re-simulated the result of Buffalo vs. Florida International, forming part of our college football predictions coverage.

Our famous predictive model gives Florida International a 76.8% chance of beating Buffalo. Our predicted final score has Florida International winning 28-20. According to our model, Buffalo (+8.5) has a 50.3% chance of covering the spread, while the over/under total of 47.5 points has a 53.4% chance of going over.

Latest betting odds

We have sourced the best college football odds in America for this game, which are listed here:

• Spread: Buffalo +8.5 (-105) / Florida International -8.5 (-109)
• Moneyline: Buffalo +340, Florida International -335
• Total: Over/Under 47.5 (-110/-106)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Buffalo +8.5 @ -105 via bet365
• Moneyline: Florida International @ -335 via FanDuel
• Total: Over 47.5 @ -110 via bet365

According to our college football best bets, the top play to make on this game is Over 47.5 total points.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football action between Florida International and Buffalo at Pitbull Stadium is scheduled to begin at 6:00 PM ET.

• Who: Buffalo vs. Florida International
• Date: Saturday, September 12, 2026
• Time: 6:00 PM ET/3:00PM PT
• Venue: Pitbull Stadium

College football Week 2 promos

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Conclusion

We predict Florida International, with a 76.8% win probability, will likely beat Buffalo in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.