Astros vs. Cubs Prediction, Picks and Odds

Our detailed prediction and analysis for the Astros vs. Cubs MLB game on May 22, 2026 is featured below. Drawing from 10,000 game simulations, we provide expert picks, betting odds, and insights.
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MLB
Astros
Spencer Arrighetti 5-1, 1.50 ERA
4
2
Wrigley Field
Cubs
Jameson Taillon 2-3, 4.97 ERA
Wrigley Field
1 2 3 4 5 6 7 8 9 RHE
Astros
0 0 1 2 1 0 0 0 0 4 9 2
Cubs
0 0 0 0 0 2 0 0 0 2 4 0
Live Probabilities
Win %
  • Astros
    100%
  • Cubs
    0%
Win Probability
Baseball infield diamond diagram
Last At Bat
Outs
Ian Happ pops out to shallow right field to Christian Walker.
Quick Box Score
Astros Hitting
No.PlayerPosABRHRBIHRBBSOAVGOPS
1 J. Peña SS5010001.2000.400
2 I. Paredes 3B4110010.2500.650
3 Y. Alvarez DH3010021.3330.933
4 C. Walker 1B5110003.2000.400
5 J. Meyers CF4010001.2500.500
6 N. Allen 2B0000000.0000.000
7 C. Smith RF4010001.2500.500
8 Z. Cole LF4001001.0000.000
9 C. Vázquez C4122101.5001.750
Cubs Hitting
No.PlayerPosABRHRBIHRBBSOAVGOPS
1 N. Hoerner 2B4000011.0000.200
2 M. Busch 1B3000010.0000.400
3 A. Bregman 3B3010010.3330.933
4 I. Happ LF5010002.2000.600
5 S. Suzuki RF4000000.0000.000
6 M. Ballesteros DH1000000.0000.000
7 C. Kelly C3000001.0000.250
8 P. Crow-Armstrong CF2112120.5002.750
9 D. Swanson SS4000001.0000.000

Astros vs. Cubs: Detailed Breakdown

Matchup Overview

  • Teams: Astros vs. Cubs
  • Date: Friday, May 22, 2026
  • Time: 2:20 PM ET
  • Venue: Wrigley Field

Current Betting Odds

  • Spread: Cubs favored at -1.5
  • Total (Over/Under): 6.5
  • Moneyline Odds: Astros 43¢, Cubs 58¢

Dimers' Win Probabilities

  • Astros: 43%
  • Cubs: 57%

Dimers' predictive model, renowned for its accuracy, assesses each team's chances by simulating the outcome of the game 10,000 times. This method provides a precise and unbiased view.

Our Prediction: Who Wins?

After extensive simulations, our model gives the Astros a win probability of 43%, while the Cubs have a win probability of 57%. Discover the best spread, over/under, and moneyline odds for the game on this page.

Summary

According to our analysis, the Cubs are more likely to beat the Astros in the MLB game at Wrigley Field on Friday. Discover the best spread, over/under and moneyline odds, picks and probabilities for the game on this page.

Our Astros vs. Cubs predictions, based on sophisticated simulations and current data, guide you in making informed decisions. Remember to bet responsibly and within your financial limits.

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For further insights, explore our expert MLB predictions and the best MLB bets today, while our in-depth analysis includes MLB props, MLB futures, MLB odds, and the latest MLB news.