Flyers vs. Sabres Prediction, Picks & Odds
Moneyline
- Flyers
- Sabres
- Porter Martone27.7%
- Trevor Zegras26.9%
- Matvei Michkov25.9%
- Oliver Bonk
- Alex Bump
- Tage Thompson39.7%
- Jack Quinn25.8%
- Jason Zucker25.6%
- Josh Doan
- Noah Ostlund
Flyers vs. Sabres prediction & analysis
Game overview: NHL Wednesday
- Teams: Philadelphia Flyers vs. Buffalo Sabres
- Date: Wednesday, October 21, 2026
- Puck drop: 7:30PM ET
- Venue: KeyBank Center
Current betting odds
- Puck line: Flyers (+1.5, -150), Sabres (-1.5, +147)
- Moneyline: Flyers +167, Sabres -170
- Total (Over/Under): 6 goals (-109/-110)
Dimers’ win probabilities
- Flyers: 38.8%
- Sabres: 61.2%
Our NHL win probabilities come from a machine learning model that assesses each team’s offensive and defensive performance, calculating multiple factors and accounting for OT and shootout chances.
It draws from these projections to forecast probabilities for the moneyline, puck line, and total goals.
Flyers vs. Sabres player props & projections
Our highest anytime goalscorer probabilities for this game are:
- Porter Martone, Flyers: 27.8%
- Matvei Michkov, Flyers: 27.4%
- Tage Thompson, Sabres: 38.8%
- Jason Zucker, Sabres: 25.6%
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Our Prediction: Who Wins?
After extensive simulations, our model gives the Flyers a win probability of 38.8%, while the Sabres have a win probability of 61.2%.
Summary
According to our analysis, the Sabres are more likely to beat the Flyers in the NHL game at KeyBank Center on Wednesday.
That is the straight-up read. Whether either side is worth backing depends on the price, which is what our betting model rates.
Responsible gambling
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