Lions vs. Panthers prediction: Why Detroit is favored to win SNF Week 4 [2026]

Since our Lions-Panthers predictions earlier in the week, we have re-simulated the result of Sunday's NFL game between the Lions and Panthers, forming part of our NFL predictions coverage.

Our independent predictive model currently gives the Lions a 63.7% chance of defeating the Panthers in Week 4 of the NFL season. Our predicted final score has the Lions winning 27-23.

Key factors favoring the Lions:

• Detroit Lions Offense
• Detroit Lions Team Rating
• Carolina Panthers Offense

According to our model, the Lions (-3.5) have a 51.4% chance of covering the spread, while the 51.5-point over/under has a 55.0% chance of staying under.

The main contributing factors to the under being more likely are:

• Carolina Panthers Pace
• Detroit Lions Pace

To see win probabilities for every matchup this week, check out our expert NFL Week 4 straight up picks.

Latest betting odds

We have researched the best NFL odds in America for this game, which are listed here:

• Spread: Lions -3.5 (-106) / Panthers +3.5 (+104)
• Moneyline: Lions -182, Panthers +178
• Total: Over/Under 51.5 (+100/-104)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Lions -3.5 @ 51¢ via Novig
• Moneyline: Panthers @ 36¢ via Novig
• Total: Under 51.5 @ 51¢ via Novig

According to our NFL best bets, the top play to make on this game is Under 51.5 total points.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Lions vs. Panthers TD scorers

Who will score a touchdown in Lions vs. Panthers?

According to our list of touchdown scorer predictions for Week 4, Jahmyr Gibbs is most likely to score an anytime TD in Lions vs. Panthers.

Our projections give Gibbs a 69.9% chance of scoring a TD at Bank of America Stadium, while the running back is a 20.0% chance of scoring the first touchdown the game.

Anytime touchdown scorer predictions

Detroit Lions

• Jahmyr Gibbs (RB): 69.9% probability
• Amon-Ra St. Brown (WR): 50.6%
• Sam LaPorta (TE): 28.8%
• Jameson Williams (WR): 27.1%
• Isaac TeSlaa (WR): 14.7%

Carolina Panthers

• Chuba Hubbard (RB): 50.5% prob.
• Tetairoa McMillan (WR): 35.6%
• Jalen Coker (WR): 32.2%
• Darren Waller (TE): 29.4%
• Bryce Young (QB): 18.0%

First touchdown scorer predictions

Detroit Lions

• Jahmyr Gibbs (RB): 20.0% prob.
• Amon-Ra St. Brown (WR): 11.8%
• Sam LaPorta (TE): 5.7%
• Jameson Williams (WR): 5.3%
• Isaac TeSlaa (WR): 2.6%

Carolina Panthers

• Chuba Hubbard (RB): 10.9% prob.
• Tetairoa McMillan (WR): 6.8%
• Jalen Coker (WR): 6.0%
• Darren Waller (TE): 5.4%
• Bryce Young (QB): 3.1%

Top player props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Lions and Panthers. Head to our NFL player projections page now to access a full list of player prop projections for every offensive player in this matchup and all other Week 4 games.

Quarterbacks

Of the starting quarterbacks, the Lions' Jared Goff is projected for 257 passing yards, while the Panthers' Bryce Young is expected to throw for 245 yards.

Lions rushing

• Jahmyr Gibbs: 99 yds
• Sione Vaki: 15 yds
• Jared Goff: 4 yds

Panthers rushing

• Chuba Hubbard: 65 yds
• Bryce Young: 16 yds
• AJ Dillon: 15 yds

Lions receiving

• Amon-Ra St. Brown: 82 yds
• Jameson Williams: 54 yds
• Sam LaPorta: 48 yds
• Jahmyr Gibbs: 39 yds
• Isaac TeSlaa: 24 yds

Panthers receiving

• Tetairoa McMillan: 75 yds
• Jalen Coker: 56 yds
• Darren Waller: 36 yds
• Chuba Hubbard: 22 yds
• Brycen Tremayne: 22 yds

Game info & kickoff details

The NFL Week 4 matchup between the Panthers and Lions at Bank of America Stadium is scheduled to begin at 8:20 PM ET.

• Who: Detroit Lions vs. Carolina Panthers
• Date: Sunday, October 4, 2026
• Time: 8:20 PM ET/5:20PM PT
• Venue: Bank of America Stadium

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Conclusion

We predict the Lions, with a 63.7% win probability, will likely beat the Panthers in Week 4 of the NFL season.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary NFL prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.