Vanderbilt vs. Virginia Tech prediction: Virginia Tech favored to win in college football Week 2, 2025

Virginia Tech will square off with Vanderbilt in Week 2 college football action at Lane Stadium on Saturday, starting at 7:30PM ET.

Based on updated simulations, Dimers' proven college football model predicts Virginia Tech as the most likely winner of today's game.

For a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Vanderbilt vs. Virginia Tech predictions page.

Vanderbilt vs. Virginia Tech prediction: Who will win, cover the spread?

Using powerful machine learning and data, we have simulated the result of Vanderbilt vs. Virginia Tech 10,000 times as part of our college football predictions coverage.

Our independent predictive model currently gives Virginia Tech a 54% chance of defeating Vanderbilt. Our predicted final score has Virginia Tech winning 23-22.

According to our model, Vanderbilt (+2.5) has a 52% chance of covering the spread, while the over/under total of 45.5 points has a 55% chance of staying under.

Vanderbilt vs. Virginia Tech odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	Vanderbilt	Virginia Tech
Spread	+2.5 (-110)	-2.5 (-105)
Moneyline	+112	-130
Total	o45.5 (-105)	u45.5 (-105)

All odds are correct at the time of publication and are subject to change.

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Vanderbilt vs. Virginia Tech picks and best bets

Our model's strongest edge in today's Vanderbilt vs. Virginia Tech matchup is on the spread.

Our expert predictions, aligned with the latest odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Vanderbilt vs. Virginia Tech game-day updates and essential details

Saturday's college football action between Virginia Tech and Vanderbilt at Lane Stadium is scheduled to commence at 7:30PM ET.

• Who: Vanderbilt vs. Virginia Tech
• Date: Saturday, September 6, 2025
• Time: 7:30PM ET/4:30PM PT
• Venue: Lane Stadium

Dimers.com's comprehensive preview of Saturday's Vanderbilt vs. Virginia Tech matchup includes our prediction, picks and the latest betting odds.

Before making any Vanderbilt vs. Virginia Tech picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Virginia Tech, with a 54% win probability, will likely beat Vanderbilt on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Vanderbilt vs. Virginia Tech insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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