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UCLA vs. Southern California prediction: Southern California favored to win in college football Week 14, 2025
Updated: | First published:
Written by Mac Douglass, Senior Editor
Get UCLA vs Southern California predictions for college football Saturday.
Southern California will take on UCLA in Week 14 college football action at Los Angeles Memorial Coliseum on Saturday, beginning at 7:30PM ET.
Based on the latest simulation results, Dimers' advanced college football model predicts Southern California as the most likely winner of the UCLA vs. Southern California game.
This article offers further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks.
UCLA vs. Southern California prediction: Who will win and cover?
Using innovative machine learning and data, we have simulated the result of UCLA vs. Southern California 10,000 times as part of our college football predictions coverage.
Our famous predictive model currently gives Southern California a 91% chance of beating UCLA. Our predicted final score has Southern California winning 38-17.
According to our model, UCLA (+21.5) has a 53% chance of covering the spread, while the over/under total of 58.5 points has a 56% chance of going over.
UCLA vs. Southern California odds
We have sourced the best college football odds in America for this game, which are listed here:
| Bet Type | UCLA | Southern California |
|---|---|---|
| Spread | +21.5 (-105) | -21.5 (-105) |
| Moneyline | +1040 | -1600 |
| Total | o58.5 (-110) | u58.5 (-106) |
All odds are correct at the time of publication and are subject to change.
UCLA vs. Southern California picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | UCLA +21.5 | -105 |
| Moneyline | UCLA | +1040 |
| Total | Over 58.5 | -110 |
According to our college football best bets, the top play to make on this game is Over 58.5 total points.
UCLA vs. Southern California game-day updates and essential details
Saturday's college football matchup between Southern California and UCLA at Los Angeles Memorial Coliseum is scheduled to commence at 7:30PM ET.
- Who: UCLA vs. Southern California
- Date: Saturday, November 29, 2025
- Time: 7:30PM ET/4:30PM PT
- Venue: Los Angeles Memorial Coliseum
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Conclusion
We predict Southern California, with a 91% win probability, will likely beat UCLA on Saturday.
AI and automation have enhanced this article to quickly deliver accurate UCLA vs. Southern California insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.
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