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Real Madrid vs. Atletico Madrid prediction, odds, La Liga picks [3/22/2026]

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Written by Damien Souness

Get Real Madrid vs Atletico Madrid predictions for La Liga Sunday.

Real Madrid-Atletico Madrid Predictions and Game Preview.
Real Madrid vs. Atletico Madrid La Liga prediction for Sunday, March 22, 2026.

Real Madrid will face Atletico Madrid in La Liga action on Sunday, beginning at 4:00 PM ET.

Based on updated simulation results, Dimers' advanced La Liga model predicts Real Madrid as the most likely winner of the Real Madrid vs. Atletico Madrid game.

This article offers further insights into Sunday's matchup, including best bets and picks.

Real Madrid vs. Atletico Madrid prediction: Who will win?

Using powerful machine learning and data, we have simulated the result of Sunday's La Liga match between Real Madrid and Atletico Madrid 10,000 times as part of our La Liga predictions coverage.

Our independent predictive model currently suggests a 47.8% chance of Real Madrid winning, a 28.6% chance for Atletico Madrid, and a 23.7% chance of a draw.

Additionally, the 2.5-goal over/under has a 58% chance of going over, according to our model.

 

Real Madrid vs. Atletico Madrid odds

We have researched the best La Liga odds in America for this game, which are listed here:

Moneyline

Real Madrid Atletico Madrid Draw
-105 +260 +280

Total Goals

Over 2.5 Under 2.5
-175 +142

All odds are correct at the time of publication and are subject to change.

Real Madrid vs. Atletico Madrid picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

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Written by
Damien Souness
Chief Innovation Officer

Damien Souness leverages over 15 years of experience to create engaging content focused on sports, online gaming and wagering. As Chief Innovation Officer at Cipher Sports Technology Group, the parent company of Dimers, he offers strategic insights and innovative solutions to enhance the player experience.

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