Ohio vs. Buffalo prediction: Ohio favored to win Black Friday College Football matchup

Buffalo will face the favored Ohio in Week 14 college football action at UB Stadium on Friday, with kickoff at 12:00PM ET.

Based on the latest simulations, Dimers' advanced college football model predicts Ohio as the most likely winner of the Ohio vs. Buffalo game.

This article offers a closer look at Friday's matchup, including an expanded look at the predicted score, best bets and picks.

Ohio vs. Buffalo prediction: Who will win and cover?

Using innovative machine learning and statistical analysis, we have simulated the outcome of Ohio vs. Buffalo 10,000 times as part of our college football predictions coverage.

Our famous predictive model gives Ohio a 70% chance of beating Buffalo. Our predicted final score has Ohio winning 26-19.

According to our model, Buffalo (+7.5) has a 55% chance of covering the spread, while the over/under total of 44.5 points has a 53% chance of staying under.

Ohio vs. Buffalo odds

We have sourced the best college football odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Ohio vs. Buffalo picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our college football best bets, the top play to make on this game is Under 44.5 total points.

Ohio vs. Buffalo game-day updates and essential details

Friday's college football matchup between Buffalo and Ohio at UB Stadium is scheduled to commence at 12:00PM ET.

• Who: Ohio vs. Buffalo
• Date: Friday, November 28, 2025 (Black Friday)
• Time: 12:00PM ET/9:00AM PT
• Venue: UB Stadium

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Conclusion

We predict Ohio, with a 70% win probability, will likely beat Buffalo on Black Friday.

AI and automation have enhanced this article to quickly deliver accurate Ohio vs. Buffalo insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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