Ole Miss vs. Mississippi State prediction: Why Mississippi is favored to win Black Friday College Football matchup, 2025

Mississippi State will square off with the favored Mississippi in Week 14 college football action at Davis Wade Stadium at Scott Field on Friday, starting at 12:00PM ET.

Based on updated simulations, Dimers' advanced college football model predicts Mississippi as the most likely winner of the Ole Miss vs. Mississippi State game.

This article offers a closer look at Friday's matchup, including an expanded look at the predicted score, best bets and picks.

Ole Miss vs. Mississippi State prediction: Who will win and cover?

Using innovative machine learning and statistical analysis, we have simulated the outcome of Ole Miss vs. Mississippi State 10,000 times as part of our college football predictions coverage.

Our independent predictive model gives Mississippi a 66% chance of beating Mississippi State. Our predicted final score has Mississippi winning 33-26.

According to our model, Mississippi State (+7.5) has a 55% chance of covering the spread, while the over/under total of 63.5 points has a 54% chance of going over.

Ole Miss vs. Mississippi State odds

We have sourced the best college football odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Ole Miss vs. Mississippi State picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our college football best bets, the top play to make on this game is Mississippi State to win.

Ole Miss vs. Mississippi State game-day updates and essential details

Friday's college football action between Mississippi State and Ole Miss at Davis Wade Stadium at Scott Field is scheduled to begin at 12:00PM ET.

• Who: Mississippi vs. Mississippi State
• Date: Friday, November 28, 2025 (Black Friday)
• Time: 12:00PM ET/9:00AM PT
• Venue: Davis Wade Stadium at Scott Field

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Conclusion

We predict Mississippi, with a 66% win probability, will likely beat Mississippi State on Black Friday.

AI and automation have enhanced this article to quickly deliver accurate Mississippi vs. Mississippi State insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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