Dodgers vs. Diamondbacks prediction: Cy Young candidate Yoshinobu Yamamoto takes on Arizona today [9/25/2025]

MLB action continues on Thursday at 3:40PM ET as the Los Angeles Dodgers take on the Arizona Diamondbacks at Chase Field.

Jalen Beeks (5-2, 3.68 ERA) will be the starting pitcher for the Diamondbacks, pitting him against Cy Young hopeful Yoshinobu Yamamoto (11-8, 2.58 ERA) for the Dodgers.

Based on updated simulations, Dimers' advanced MLB model projects the Dodgers as the most likely winner of today's game.

For a closer look at Thursday's matchup, including best bets and picks, visit our interactive Dodgers vs. Diamondbacks predictions page.

Diamondbacks vs. Dodgers prediction: Who will win, cover the run line?

Using powerful machine learning and data analysis, we have simulated the outcome of Thursday's MLB matchup between the Dodgers and Diamondbacks 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Dodgers a 60% chance of defeating the Diamondbacks.

According to our model, the Diamondbacks (+1.5) have a 52% chance of covering the run line, while the over/under total of 8.5 runs has a 57% chance of going over.

Dodgers vs. Diamondbacks odds [9/25/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Dodgers	Diamondbacks
Run Line	-1.5 (+102)	+1.5 (-115)
Moneyline	-163	+140
Total	o8.5 (-106)	u8.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Dodgers vs. Diamondbacks picks and best bets

Our model's strongest edge in today's Dodgers vs. Diamondbacks matchup is on the run line.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free MLB picks

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Dodgers vs. Diamondbacks game-day updates and essential details

Thursday's MLB game between the Diamondbacks and Dodgers at Chase Field is scheduled to begin at 3:40PM ET.

• Who: Los Angeles Dodgers vs. Arizona Diamondbacks
• Date: Thursday, September 25, 2025
• Time: 3:40PM ET/12:40PM PT
• Venue: Chase Field

Dimers' full preview of Thursday's Dodgers vs. Diamondbacks matchup includes our prediction, picks and the latest betting odds.

Before making any Dodgers vs. Diamondbacks picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Dodgers, with a 60% win probability, will likely beat the Diamondbacks on Thursday.

AI and automation have enhanced this article to quickly deliver accurate Dodgers vs. Diamondbacks insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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