Indianapolis Colts vs. Kansas City Chiefs updated prediction featuring Jonathan Taylor, Rashee Rice [Week 12, 2025]

Dimers' latest NFL predictions are live for Kansas City Chiefs vs. Indianapolis Colts in Week 12, with our model giving the Chiefs a 62% of winning.

As Sunday approaches, both teams have updated their injury reports. A few lineup decisions are still up in the air, and those could shape how each side approaches this AFC clash.

Since our early Chiefs-Colts predictions, we’ve updated the win probabilities, score projections, and TD odds for Jonathan Taylor, Rashee Rice, and others.

For the full simulation breakdown—including spreads, totals, touchdown probabilities, and the full list of player props—head to our Colts vs. Chiefs page.

What's changed? Indianapolis vs. Kansas City updated predictions

Our NFL predictions model has been re-run with the newest available data, creating a clearer picture of how this Colts vs. Chiefs matchup stacks up. Here are the updated forecasts:

• Straight Up Win Probabilities: Colts 38%, Chiefs 62%
• Predicted Final Score: Colts 23-26 Chiefs
• Spread: Colts (+3.5) 50%, Chiefs (-3.5) 50%
• Total Points (49.5): Over 53%, Under 47%

As of November 20, 2025, these Colts-Chiefs calculations reflect changes since our early-week simulation.

Anytime touchdown scorer predictions

New NFL player projections for Week 12 highlight the top candidates to find the end zone in Colts-Chiefs on Sunday:

Indianapolis Colts

• Jonathan Taylor: 68.8% probability
• Tyler Warren: 28.4% probability
• Michael Pittman: 26.0% probability

Kansas City Chiefs

• Rashee Rice: 45.4% probability
• Isiah Pacheco: 40.0% probability
• Kareem Hunt: 39.0% probability

Colts vs. Chiefs latest odds

The best current odds from the top sportsbooks in the US:

• Spread: Colts +3.5 (-115), Chiefs -3.5 (-102)
• Moneyline: Colts +156, Chiefs -175
• Total: Over/Under 49.5 (-115/-105)

Odds are correct at time of publication and are subject to change—track live updates via our NFL odds page.

Colts vs. Chiefs Week 12 details

The NFL Week 12 game between the Chiefs and Colts at GEHA Field at Arrowhead Stadium is scheduled for November 23, 2025.

• Who: Indianapolis Colts vs. Kansas City Chiefs
• Date: Sunday, November 23, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: GEHA Field at Arrowhead Stadium

NFL Week 12 betting promos and codes

Make the most of Dimers' Colts vs. Chiefs predictions by exploring the two exciting offers below.

DraftKings Sportsbook

Sign up for DraftKings Sportsbook! Bet $5, get $200 in bonus bets instantly plus over $200 off NFL Sunday Ticket.

Bet365 Sportsbook

Join Bet365 Sportsbook! Bet $5, get $200 in bonus bets win or lose.

Conclusion

We predict the Chiefs, with a 62% win probability, will likely beat the Colts in Week 12 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Colts vs. Chiefs matchup, with human oversight maintaining high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee.

More on NFL

Stay informed with the latest NFL betting news and data-driven parlay picks all season long. Plus, our Super Bowl odds for top predictions and the best available odds on the Super Bowl, AFC, NFC and each division.