Colorado vs. Houston prediction: Houston favored to win in college football Week 3, 2025

Houston and Colorado will meet in Week 3 college football action at TDECU Stadium on Friday, commencing at 7:30PM ET.

Based on the latest simulations, Dimers' advanced college football model predicts Houston as the most likely winner of today's game.

For a closer look at Friday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Colorado vs. Houston predictions page.

Colorado vs. Houston prediction: Who will win, cover the spread?

Using powerful machine learning and data, we have simulated the outcome of Colorado vs. Houston 10,000 times as part of our college football predictions coverage.

Our leading predictive model gives Houston a 60% chance of defeating Colorado. Our predicted final score has Houston winning 24-21.

According to our model, Colorado (+4) has a 51% chance of covering the spread, while the over/under total of 44.5 points has a 53% chance of staying under.

Colorado vs. Houston odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	Colorado	Houston
Spread	+4 (-108)	-4 (-110)
Moneyline	+160	-185
Total	o44.5 (-115)	u44.5 (-105)

All odds are correct at the time of publication and are subject to change.

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Colorado vs. Houston picks and best bets

Our model's strongest edge in today's Colorado vs. Houston matchup is on the spread.

Our expert predictions, matched against the current odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Colorado vs. Houston game-day updates and essential details

Friday's college football game between Houston and Colorado at TDECU Stadium is scheduled to begin at 7:30PM ET.

• Who: Colorado vs. Houston
• Date: Friday, September 12, 2025
• Time: 7:30PM ET/4:30PM PT
• Venue: TDECU Stadium

Dimers' in-depth preview of Friday's Colorado vs. Houston matchup includes our prediction, picks and the latest betting odds.

Before making any Colorado vs. Houston picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

Conclusion

We predict Houston, with a 60% win probability, will likely beat Colorado on Friday.

AI and automation have enhanced this article to quickly deliver accurate Colorado vs. Houston insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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