Best bets today for all sports: Sunday's picks include Gonzaga vs. Oregon men's college basketball play [12/21/2025]

Men's College Basketball: Oregon ML (+660)

• Edge: 9.4%
• Probability: 22.5%
• Men's College Basketball matchup: Gonzaga vs. Oregon (6:00PM ET, Sunday)

Our model has identified value on Oregon to defeat Gonzaga at +660 odds. A 22.5% probability produces an edge of 9.4%, making this the strongest play for today's sports action.

NFL: Cardinals +2.5 (-102)

• Edge: 7.7%
• Probability: 58.2%
• NFL matchup: Falcons vs. Cardinals (4:05PM ET, Sunday)

Cardinals +2.5 carries a 7.7% edge and a probability of 58.2% at -102 odds, according to our model.

NFL: Titans +2.5 (-102)

• Edge: 7.7%
• Probability: 58.2%
• NFL Matchup: Chiefs vs. Titans (1:00PM ET, Sunday)

Titans +2.5 vs. Chiefs at -102 odds shows a 7.7% edge, supported by a 58.2% probability in simulations.

NFL: Cardinals +2.5 (-102)

• Edge: 7.7%
• Probability: 58.2%
• NFL Matchup: Falcons vs. Cardinals (4:05PM ET, Sunday)

A 7.7% edge and 58.2% probability make Cardinals +2.5 vs. Falcons at a value play in the Falcons vs. Cardinals matchup, per our model.

Men's College Basketball: New Mexico State ML (-135)

• Edge: 7.3%
• Probability: 64.7%
• Men's College Basketball Matchup: Sam Houston State vs. New Mexico State (4:00PM ET, Sunday)

New Mexico State ML at -135 odds presents a 7.3% edge, with simulations resulting in a probability of 64.7%.

Men's College Basketball: Alabama A&M +2.5 (-102)

• Edge: 7.2%
• Probability: 57.7%
• Men's College Basketball Matchup: Chattanooga vs. Alabama A&M (3:00PM ET, Sunday)

Our model finds value on Alabama A&M +2.5 at -102 odds, supported by an edge of 7.2%.

Men's College Basketball: Gardner-Webb +40.5 (-104)

• Edge: 7.0%
• Probability: 58%
• Men's College Basketball Matchup: Gardner-Webb vs. Tennessee (3:00PM ET, Sunday)

Our model has uncovered value on Gardner-Webb +40.5 at -104 odds. A 58% probability produces a 7.0% edge, making this a strong play for today's men's college basketball action.

Men's College Basketball: Albany +5.5 (-105)

• Edge: 6.8%
• Probability: 58%
• Men's College Basketball Matchup: Cornell vs. Albany (3:00PM ET, Sunday)

A 6.8% edge on a 58% probability makes Albany +5.5 at -105 odds a solid value play in today's Cornell vs. Albany matchup.

College Basketball: La Salle +39.5 (-110)

• Edge: 6.6%
• Probability: 59%
• College Basketball Matchup: La Salle vs. Michigan (4:00PM ET, Sunday)

Our model projects value on La Salle +39.5 at -110 odds. A 59% probability produces a 6.6% edge, making La Salle the favorable side in Saturday’s college basketball matchup.

Men's College Basketball: Illinois-Chicago +2.5 (-105)

• Edge: 6.5%
• Probability: 57.7%
• Men's College Basketball Matchup: Gardner-Webb vs. Tennessee (2:00PM ET, Sunday)

Rounding out our top 10 bets, Illinois-Chicago +2.5 at -105 odds shows a 57.7% probability and a 6.5% edge.

Best sports bets today summary: Sunday, 12/21/2025

As of 4:31AM ET, here are our top bets by edge recommended by our model:

Matchup	Bet	Odds	Edge	Probability
Gonzaga vs. Oregon (Men's College Basketball)	Oregon ML	+660 @ FanDuel	9.4%	22.5%
Falcons vs. Cardinals (NFL)	Cardinals +2.5	-102 @ BetMGM	7.7%	58.2%
Chiefs vs. Titans (NFL)	Titans +2.5	-102 @ FanDuel	7.7%	58.2%
Falcons vs. Cardinals (NFL)	Cardinals +2.5	-102 @ BetMGM	7.7%	58.2%
Sam Houston State vs. New Mexico State (Men's College Basketball)	New Mexico State ML	-135 @ DraftKings	7.3%	64.7%
Chattanooga vs. Alabama A&M (Men's College Basketball)	Alabama A&M +2.5	-102 @ BetMGM	7.2%	57.7%
Gardner-Webb vs. Tennessee (Men's College Basketball)	Gardner-Webb +40.5	-104 @ FanDuel	7.0%	58%
Cornell vs. Albany (Men's College Basketball)	Albany +5.5	-105 @ DraftKings	6.8%	58%
La Salle vs. Michigan (College Basketball)	La Salle +39.5	-110 @ BetMGM	6.6%	59%
Illinois-Chicago vs. Charlotte (Men's College Basketball)	Illinois-Chicago +2.5	-105 @ BetMGM	6.5%	57.7%

List of upcoming matchups to bet on right now [12/21/2025]

• La Liga: Atletico Madrid vs. Girona (8:00AM ET, Sunday)
• La Liga: Barcelona vs. Villareal (10:15AM ET, Sunday)
• EPL: Manchester United vs. Aston Villa (11:30AM ET, Sunday)
• NCAAM: Charleston vs. Northern Kentucky (12:00PM ET, Sunday)
• NCAAM: Penn State vs. Pittsburgh (12:00PM ET, Sunday)
• NCAAM: Colgate vs. Florida (12:00PM ET, Sunday)
• NCAAM: Massachusetts-Lowell vs. Boston University (12:00PM ET, Sunday)
• La Liga: Rayo Vallecano vs. Elche (12:30PM ET, Sunday)
• NHL: Capitals vs. Red Wings (1:00PM ET, Sunday)
• NFL: Bills vs. Browns (1:00PM ET, Sunday)

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Conclusion

Our best bets are locked and loaded for December 21, 2025, featuring plays such as Oregon ML and Cardinals +2.5. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate insights quickly, with human oversight ensuring high editorial quality. Our predictions are sourced from current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.

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