Jul 23, 2026
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Read Article Twins vs. Pirates prediction: Why Pittsburgh is favored to win Friday's MLB matchup [5/29/2026]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get Minnesota Twins vs Pittsburgh Pirates predictions for MLB Friday.
The Pittsburgh Pirates will take on the Minnesota Twins in MLB action at PNC Park on Friday, starting at 6:45 PM ET.
Jared Jones (0-0, 0.00 ERA) will start for the Pirates, up against Taj Bradley (5-1, 2.77 ERA) for the Twins.
Based on the latest simulation results, Dimers' advanced MLB model predicts the Pirates as the most likely winner of the Twins vs. Pirates game.
This article offers further insights into Friday's matchup, including best bets and picks.
Twins vs. Pirates prediction: Who will win and cover?
Using powerful machine learning and data, we have simulated the outcome of Friday's MLB matchup between the Twins and Pirates, forming part of our MLB predictions coverage.
Our independent predictive model gives the Pirates a 55% chance of beating the Twins.
According to our model, the Twins (+1.5) have a 63% chance of covering the run line, while the 8-run over/under has a 54% chance of going over.
Twins vs. Pirates odds [5/29/2026]
We have sourced the best MLB odds in America for this game, which are listed here:
| Bet Type | Twins | Pirates |
|---|---|---|
| Run Line | +1.5 (-182) | -1.5 (+154) |
| Moneyline | +114 | -134 |
| Total | o8 (-111) | u8 (-109) |
All odds are correct at the time of publication and are subject to change.
Twins vs. Pirates picks and best bet
After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Twins +1.5 | -182 |
| Moneyline | Twins | +114 |
| Total | Over 8 | -111 |
According to our MLB best bets, the top play to make on this game is Over 8 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Twins vs. Pirates game-day updates and essential details
Friday's MLB matchup between the Pirates and Twins at PNC Park is scheduled to start at 6:45 PM ET.
- Who: Minnesota Twins vs. Pittsburgh Pirates
- Date: Friday, May 29, 2026
- Time: 6:45 PM ET/3:45PM PT
- Venue: PNC Park
Conclusion
We predict the Pirates, with a 55% win probability, will likely beat the Twins in Friday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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