Reds vs. Mariners prediction: Seattle favored to win Wednesday's MLB matchup [7/22/2026]
Get Cincinnati Reds vs Seattle Mariners predictions for MLB Wednesday.
The Seattle Mariners will face the Cincinnati Reds in MLB action at T-Mobile Park on Wednesday, starting at 3:40 PM ET.
The Mariners will have Emerson Hancock (6-4, 3.17 ERA) as their starting pitcher, up against Brady Singer (4-9, 4.56 ERA) for the Reds.
Based on updated simulation results, Dimers' advanced MLB model predicts the Mariners as the most likely winner of the Reds vs. Mariners game.
This article offers a closer look at Wednesday's matchup, including best bets and picks.
Reds vs. Mariners prediction: Who will win and cover?
Our leading predictive model currently gives the Mariners a 60.6% chance of beating the Reds.
According to our model, the Reds (+1.5) have a 58.5% chance of covering the run line, while the 8.5-run over/under has a 50.9% chance of staying under,.
Reds vs. Mariners odds [7/22/2026]
We have researched the best MLB odds in America for this game, which are listed here:
| Bet Type | Reds | Mariners |
|---|---|---|
| Run Line | +1.5 (-150) | -1.5 (+145) |
| Moneyline | +138 | -138 |
| Total | o8.5 (+113) | u8.5 (-117) |
All odds are correct at the time of publication and are subject to change.
Reds vs. Mariners picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Mariners -1.5 | +145 |
| Moneyline | Mariners | -138 |
| Total | Over 8.5 | +113 |
According to our MLB best bets, the top play to make on this game is Over 8.5 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Reds vs. Mariners game-day updates and essential details
Wednesday's MLB action between the Mariners and Reds at T-Mobile Park is scheduled to start at 3:40 PM ET.
- Who: Cincinnati Reds vs. Seattle Mariners
- Date: Wednesday, July 22, 2026
- Time: 3:40 PM ET/12:40PM PT
- Venue: T-Mobile Park
Conclusion
We predict the Mariners, with a 60.6% win probability, will likely beat the Reds in Wednesday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
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Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
