Orioles vs. Angels prediction: Baltimore favored to win Monday's MLB matchup [6/22/2026]

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Written by Jason Bevilacqua

Get Baltimore Orioles vs Los Angeles Angels predictions for MLB Monday.

Baltimore Orioles-Los Angeles Angels Predictions and Game Preview.
Baltimore Orioles vs. Los Angeles Angels MLB prediction for Monday, June 22, 2026.

The Los Angeles Angels will square off with the Baltimore Orioles in MLB action at Angel Stadium on Monday, beginning at 9:38 PM ET.

Sam Aldegheri (2-2, 4.50 ERA) will be on the bump for the Angels, while the Orioles have opted for Kyle Bradish (4-7, 4.00 ERA).

Based on updated simulations, Dimers' proven MLB model predicts the Orioles as the most likely winner of the Orioles vs. Angels game.

This article offers further insights into Monday's matchup, including best bets and picks.

Orioles vs. Angels prediction: Who will win and cover?

Using innovative machine learning and data, we have simulated the result of Monday's MLB game between the Orioles and Angels, forming part of our MLB predictions coverage.

Our independent predictive model gives the Orioles a 60.7% chance of defeating the Angels.

According to our model, the Angels (+1.5) have a 51.3% chance of covering the run line, while the 9-run over/under has a 54.4% chance of going over,.

 

Orioles vs. Angels odds [6/22/2026]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type Orioles Angels
Run Line -1.5 (+104) +1.5 (-118)
Moneyline -158 +136
Total o9 (-106) u9 (-110)

All odds are correct at the time of publication and are subject to change.

Orioles vs. Angels picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type Pick Bet Now
Run Line Orioles -1.5 +104
Moneyline Orioles -158
Total Over 9 -106

According to our best MLB bets, the top play to make on this game is Over 9 total runs.

These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.

 

Orioles vs. Angels game-day updates and essential details

Monday's MLB matchup between the Angels and Orioles at Angel Stadium is scheduled to commence at 9:38 PM ET.

Conclusion

We predict the Orioles, with a 60.7% win probability, will likely beat the Angels in Monday's MLB matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

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Written by
Jason Bevilacqua
Head of Content and Communities

Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.

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