Pumas UNAM vs. San Luis prediction, odds, Liga MX picks [9/27/2026]

Pumas UNAM and Atletico San Luis are scheduled to meet in Liga MX on Sunday, starting at 2:00 PM ET.

Dimers' proven Liga MX model projects Pumas UNAM as the most likely winner in this Pumas UNAM vs. Atletico San Luis prediction.

This article offers further insights into Sunday's match, including best bets and picks.

Pumas UNAM vs. Atletico San Luis prediction and odds

Using innovative machine learning and statistical analysis, we have re-simulated the result of Sunday's Liga MX matchup between Pumas UNAM and Atletico San Luis, forming part of our Liga MX predictions coverage.

Our leading predictive model currently indicates a 55.2% chance of Pumas UNAM winning, a 21.7% chance for Atletico San Luis, and a 23.1% chance of a draw. Additionally, the 2.5-goal over/under has a 53.9% chance of going over., with a 53.8% probability that both teams find the net.

Latest betting odds

We have researched the best Liga MX odds in America for this game, which are listed here:

• Moneyline: Atletico San Luis +245, Pumas UNAM +105
• Total Goals: Over/Under 2.5 (-138/+112)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Moneyline: Pumas UNAM @ +105 via DraftKings
• Total Goals: Under 2.5 @ +112 via FanDuel

According to our Liga MX best bets, the top play to make on this game is Pumas UNAM to win.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Correct score and BTTS projections

Here are the top three most likely final scores according to our model, with a 1-1 draw being the most probable:

• Pumas UNAM 1-1 San Luis (11% probability)
• Pumas UNAM 1-0 San Luis (10.6%)
• Pumas UNAM 2-1 San Luis (9.8%)

When it comes to the both teams to score (BTTS) market, we project a 53.8% chance of both sides finding the net and a 46.2% chance that at least one doesn’t.

These predictions are based on each team's average score according to our machine learning model, meaning the most likely correct score can differ from our predicted winner.

Game info & kickoff details

Sunday's Liga MX action between Pumas UNAM and Atletico San Luis is scheduled to commence at 2:00 PM ET.

• Who: Pumas UNAM vs. Atletico San Luis
• Date: Sunday, September 27, 2026
• Time: 2:00 PM ET/11:00AM PT

Conclusion

According to our computer model, Pumas UNAM has a 55.2% win probability on Sunday, Atletico San Luis has a 21.7% win probability, and there is a 23.1% chance that the game will end in a draw.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary Liga MX prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.