James Madison vs. Southern Miss: College Football Week 10 Prediction, Picks & Odds

James Madison vs. Southern Miss: Detailed Breakdown

Matchup overview: College Football Week 10

• Teams: James Madison vs. Southern Miss
• Date: Thursday, November 5, 2026
• Time: 8:00PM ET
• Venue: M.M. Roberts Stadium

Current betting odds

• Spread: James Madison (-14, -110), Southern Miss (+14, -110)
• Moneyline: James Madison -520, Southern Miss +440
• Total (Over/Under): 54.5 points (-115/-105)

Dimers’ win probabilities

• James Madison: 80.3%
• Southern Miss: 19.7%

These probabilities come from two machine learning models that assess more than 100 data points for each college football matchup, combining their outputs to project all our major betting markets.

Projected final score

Our predicted final score for this college football matchup is James Madison 33-21 Southern Miss.

This prediction draws on each team's scoring trends and player stats, weighed across both of our data models

Our Prediction: Who Wins?

The numbers give the James Madison a win probability of 80.3%, while the Southern Miss have a win probability of 19.7%.

Summary

James Madison faces off against Southern Miss in college football action at M.M. Roberts Stadium on Thursday, November 5, 2026.

Our James Madison vs. Southern Miss predictions, built on real-time data and matchup-specific modeling, help guide your decisions. Remember to bet responsibly and within your financial limits.

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For further insights, explore our expert college football predictions and the best college football bets today, while our in-depth analysis includes college football props, college football futures, college football odds, and the latest college football news.