Clemson vs. Syracuse: College Football Week 10 Prediction, Picks & Odds
Spread
- Clemson
- Syracuse
Clemson vs. Syracuse: Detailed Breakdown
Matchup overview: College Football Week 10
- Teams: Clemson vs. Syracuse
- Date: Saturday, November 7, 2026
- Time: 12:00PM ET
- Venue: JMA Wireless Dome
Current betting odds
- Spread: Clemson (-1.5, -105), Syracuse (+1.5, -112)
- Moneyline: Clemson -113, Syracuse -104
- Total (Over/Under): 49.5 points (-110/-110)
Dimers’ win probabilities
- Clemson: 54.0%
- Syracuse: 46.0%
These probabilities come from two machine learning models that assess more than 100 data points for each college football matchup, combining their outputs to project all our major betting markets.
Projected final score
Our predicted final score for this college football matchup is Clemson 26-24 Syracuse.
This prediction draws on each team's scoring trends and player stats, weighed across both of our data models
Our Prediction: Who Wins?
The numbers give the Clemson a win probability of 54.0%, while the Syracuse have a win probability of 46.0%.
Summary
Clemson faces off against Syracuse in college football action at JMA Wireless Dome on Saturday, November 7, 2026.
Our Clemson vs. Syracuse predictions, built on real-time data and matchup-specific modeling, help guide your decisions. Remember to bet responsibly and within your financial limits.
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For further insights, explore our expert college football predictions and the best college football bets today, while our in-depth analysis includes college football props, college football futures, college football odds, and the latest college football news.