Southern Miss vs. Tulane prediction: Why Tulane is favored to win in college football Week 4 [2026]

Using powerful machine learning and data, we have re-simulated the result of Southern Miss vs. Tulane, forming part of our college football predictions coverage.

Our independent predictive model gives Tulane a 90.3% chance of beating Southern Miss. Our predicted final score has Tulane winning 35-17. According to our model, Southern Miss (+18.5) has a 52.0% chance of covering the spread, while the 52.5-point over/under has a 50.4% chance of going over.

Latest betting odds

We have researched the best college football odds in America for this game, which are listed here:

• Spread: Southern Miss +18.5 (-112) / Tulane -18.5 (-108)
• Moneyline: Southern Miss +800, Tulane -1100
• Total: Over/Under 52.5 (-107/-110)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Southern Miss +18.5 @ -112 via FanDuel
• Moneyline: Tulane @ -1100 via bet365
• Total: Over 52.5 @ -107 via Caesars

According to our college football best bets, the top play to make on this game is Southern Miss +18.5 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football game between Tulane and Southern Miss at Yulman Stadium is scheduled to start at 7:00 PM ET.

• Who: Southern Miss vs. Tulane
• Date: Saturday, September 26, 2026
• Time: 7:00 PM ET/4:00PM PT
• Venue: Yulman Stadium

College football Week 4 promos

Make the most of Dimers' Southern Miss vs. Tulane predictions by exploring the Bet365 Sportsbook offer below:

Conclusion

We predict Tulane, with a 90.3% win probability, will likely beat Southern Miss in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.