South Dakota State vs. Southern Illinois prediction favors South Dakota State to win in college football Week 11 [2026]

Using trusted machine learning and data analysis, we have re-simulated the result of South Dakota State vs. Southern Illinois, forming part of our college football predictions coverage.

Our leading predictive model gives South Dakota State an 86.0% chance of defeating Southern Illinois. Our predicted final score has South Dakota State winning 33-18. According to our model, Southern Illinois (+16.5) has a 52.5% chance of covering the spread, while the 51.5-point over/under has a 52.1% chance of going over.

Latest betting odds

We have researched the best college football odds in America for this game, which are listed here:

• Spread: South Dakota State -16.5 (-104) / Southern Illinois +16.5 (-104)
• Moneyline: South Dakota State -590, Southern Illinois +567
• Total: Over/Under 51.5 (+102/-108)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Southern Illinois +16.5 @ 51¢ via Novig
• Moneyline: South Dakota State @ 86¢ via Novig
• Total: Over 51.5 @ 50¢ via Novig

According to our college football best bets, the top play to make on this game is Over 51.5 total points.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football action between Southern Illinois and South Dakota State at Saluki Stadium is scheduled to begin at 2:00 PM ET.

• Who: South Dakota State vs. Southern Illinois
• Date: Saturday, November 14, 2026
• Time: 2:00 PM ET/11:00 AM PT
• Venue: Saluki Stadium

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Conclusion

We predict South Dakota State, with an 86.0% win probability, will likely beat Southern Illinois in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary college football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.