South Carolina vs. Florida prediction favors Florida to win in college football Week 6 [2026]

Florida will square off with South Carolina in Week 6 college football action at Ben Hill Griffin Stadium on Saturday, beginning at 12:45 PM ET.

Dimers' proven college football model projects Florida as the most likely winner in this South Carolina vs. Florida prediction.

This article offers further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

South Carolina vs. Florida prediction and odds

Using powerful machine learning and data, we have re-simulated the outcome of South Carolina vs. Florida, forming part of our college football predictions coverage.

Our independent predictive model gives Florida an 83.0% chance of defeating South Carolina. Our predicted final score has Florida winning 35-23. According to our model, Florida (-10.5) has a 53.0% chance of covering the spread, while the 59-point over/under has a 51.2% chance of going over.

Latest betting odds

We have researched the best college football odds in America for this game, which are listed here:

• Spread: South Carolina +10.5 (-107) / Florida -10.5 (-111)
• Moneyline: South Carolina +370, Florida -440
• Total: Over/Under 59 (-109/-114)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Florida -10.5 @ -111 via bet365
• Moneyline: Florida @ -440 via FanDuel
• Total: Over 59 @ -109 via BetRivers

According to our best college football bets, the top play to make on this game is Florida to win.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football game between Florida and South Carolina at Ben Hill Griffin Stadium is scheduled to start at 12:45 PM ET.

• Who: South Carolina vs. Florida
• Date: Saturday, October 10, 2026
• Time: 12:45 PM ET/9:45AM PT
• Venue: Ben Hill Griffin Stadium

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Conclusion

We predict Florida, with an 83.0% win probability, will likely beat South Carolina in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.