Nicholls State vs. Sam Houston State prediction favors Sam Houston State to win in college football Week 3 [2026]

Using powerful machine learning and data, we have re-simulated the outcome of Nicholls State vs. Sam Houston State, forming part of our college football predictions coverage.

Our famous predictive model gives Sam Houston State a 90.7% chance of defeating Nicholls State. Our predicted final score has Sam Houston State winning 34-16. According to our model, Nicholls State (+21.5) has a 59.6% chance of covering the spread, while the 50.5-point over/under has a 53.3% chance of going over.

Latest betting odds

We have researched the best college football odds in America for this game, which are listed here:

• Spread: Nicholls State +21.5 (-110) / Sam Houston State -21.5 (-105)
• Moneyline: Nicholls State +1160, Sam Houston State -1400
• Total: Over/Under 50.5 (-110/-108)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Nicholls State +21.5 @ -110 via bet365
• Moneyline: Nicholls State @ +1160 via FanDuel
• Total: Over 50.5 @ -110 via bet365

According to our college football best bets, the top play to make on this game is Nicholls State +21.5 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football game between Sam Houston State and Nicholls State at Elliott T. Bowers Stadium is scheduled to commence at 7:00 PM ET.

• Who: Nicholls State vs. Sam Houston State
• Date: Saturday, September 19, 2026
• Time: 7:00 PM ET/4:00PM PT
• Venue: Elliott T. Bowers Stadium

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Conclusion

We predict Sam Houston State, with a 90.7% win probability, will likely beat Nicholls State in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.