East Carolina vs. Memphis prediction: Why Memphis is favored to win in college football Week 8 [2026]

Using innovative machine learning and data analysis, we have re-simulated the outcome of East Carolina vs. Memphis, forming part of our college football predictions coverage.

Our leading predictive model currently gives Memphis an 80.3% chance of defeating East Carolina. Our predicted final score has Memphis winning 32-21. According to our model, Memphis (-10.5) has a 51.0% chance of covering the spread, while the over/under total of 53.5 points has a 53.0% chance of going over.

Latest betting odds

We have researched the best college football odds in America for this game, which are listed here:

• Spread: East Carolina +10.5 (-106) / Memphis -10.5 (+104)
• Moneyline: East Carolina +344, Memphis -365
• Total: Over/Under 53.5 (-111/+106)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Memphis -10.5 @ 49¢ via Novig
• Moneyline: Memphis @ 78¢ via Novig
• Total: Over 53.5 @ 53¢ via Novig

According to our college football best bets, the top play to make on this game is Memphis -10.5 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Thursday's college football game between Memphis and East Carolina at Simmons Bank Liberty Stadium is scheduled to begin at 7:30 PM ET.

• Who: East Carolina vs. Memphis
• Date: Thursday, October 22, 2026
• Time: 7:30 PM ET/4:30 PM PT
• Venue: Simmons Bank Liberty Stadium

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Conclusion

We predict Memphis, with an 80.3% win probability, will likely beat East Carolina in Thursday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.