Delaware State vs. William & Mary prediction: Why William & Mary is favored to win in college football Week 1 [2026]

William & Mary will face Delaware State in Week 1 college football action at Walter J. Zable Stadium at Cary Field on Saturday, beginning at 6:00 PM ET.

Dimers' proven college football model projects William & Mary as the most likely winner in this Delaware State vs. William & Mary prediction.

This article offers further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks, backed by the same system that has dominated college football and NFL betting markets across multiple seasons.

Delaware State vs. William & Mary prediction and odds

Using trusted machine learning and data, we have simulated the outcome of Delaware State vs. William & Mary, forming part of our college football predictions coverage.

Our famous predictive model currently gives William & Mary a 68.7% chance of defeating Delaware State. Our predicted final score has William & Mary winning 30-22.

According to our model, Delaware State (+9.5) has a 52.6% chance of covering the spread, while the over/under total of 56 points has a 59.2% chance of staying under.

Latest betting odds

We have researched the best college football odds in America for this game, which are listed here:

• Spread: Delaware State +9.5 (-105) / William & Mary -9.5 (-112)
• Moneyline: Delaware State +280, William & Mary -348
• Total: Over/Under 56 (-113/-109)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Delaware State +9.5 @ -105 via bet365
• Moneyline: Delaware State @ +280 via bet365
• Total: Under 56 @ -109 via Caesars

According to our college football best bets, the top play to make on this game is Under 56 total points.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football action between William & Mary and Delaware State at Walter J. Zable Stadium at Cary Field is scheduled to begin at 6:00 PM ET.

• Who: Delaware State vs. William & Mary
• Date: Saturday, September 5, 2026
• Time: 6:00 PM ET/3:00PM PT
• Venue: Walter J. Zable Stadium at Cary Field

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Make the most of Dimers' Delaware State vs. William & Mary predictions by exploring the Underdog Fantasy offfer below

Conclusion

We predict William & Mary, with a 68.7% win probability, will likely beat Delaware State in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.