College football picks today: Week 10 Friday best bets include New Mexico vs. Nevada play [11/6/2026]

New Mexico vs. Nevada Over 37.5 points (-113)

• Edge: 8.0%
• Probability: 61%
• Matchup: New Mexico vs. Nevada (9:00PM ET)

Our model has identified value on Over 37.5 points in New Mexico vs. Nevada at -113 odds. A 61% probability produces an edge of 8.0%, making this the strongest play for today's college football slate.

South Florida vs. East Carolina Over 39.5 points (-108)

• Edge: 4.8%
• Probability: 56.7%
• Matchup: South Florida vs. East Carolina (7:30PM ET)

South Florida vs. East Carolina over 39.5 points carries a 4.8% edge and a probability of 56.7% at -108 odds, according to our model.

East Carolina +1.5 (58¢)

• Edge: 2.8%
• Probability: 60.8%
• Matchup: South Florida vs. East Carolina (7:30PM ET)

East Carolina +1.5 vs. South Florida at 58¢ odds shows a 2.8% edge, supported by a 60.8% probability in simulations.

TCU vs. Arizona over 46.5 points (-105)

• Edge: 2.5%
• Probability: 53.7%
• Matchup: TCU vs. Arizona (10:15PM ET)

A 2.5% edge and 53.7% probability make TCU vs. Arizona over 46.5 points a value play in the TCU vs. Arizona matchup, per our model.

Southern Methodist -7.5 (+130)

• Edge: 2.0%
• Probability: 45.5%
• Matchup: Virginia Tech vs. Southern Methodist (7:00PM ET)

Southern Methodist -7.5 at 44¢ presents a 2.0% edge, with simulations resulting in a probability of 45.5%.

Southern Methodist ML (-203)

• Edge: 2.0%
• Probability: 69%
• Matchup: Virginia Tech vs. Southern Methodist (7:00PM ET)

Our model finds value on Southern Methodist to win at 67¢, supported by an edge of 2.0%.

NCAAF best bets summary: Friday, 11/6/2026

As of 1:31AM ET, here are our top college football bets by edge recommended by our model:

List of upcoming college football games to bet on now

• Virginia Tech vs. Southern Methodist (7:00PM ET, Friday)
• South Florida vs. East Carolina (7:30PM ET, Friday)
• Nebraska vs. Illinois (8:00PM ET, Friday)
• New Mexico vs. Nevada (9:00PM ET, Friday)
• TCU vs. Arizona (10:15PM ET, Friday)

College football offer for Week 10

Make the most of the picks in this article, including Over 37.5 points, with the Underdog Fantasy offer below:

Conclusion

Our college football best bets are locked and loaded for November 6, 2026, featuring plays such as over 37.5 points in the New Mexico vs. Nevada matchup and over 39.5 points in the South Florida vs. East Carolina matchup. Powered by advanced simulations, these picks are here to boost your betting game.

Our predictions are drawn from current data to help you make informed decisions. For additional resources and advice, head to our Responsible Gambling hub.

All odds and probabilities in this article are correct and accurate at the time of publication.