Charleston Southern vs. Clemson prediction: Why Clemson is favored to win in college football Week 7 [2026]

Using innovative machine learning and data analysis, we have re-simulated the outcome of Charleston Southern vs. Clemson, forming part of our college football predictions coverage.

Our leading predictive model gives Clemson a 99.7% chance of beating Charleston Southern. Our predicted final score has Clemson winning 47-5. According to our model, Charleston Southern (+42.5) has a 50.7% chance of covering the spread, while the 54.5-point over/under has a 52.2% chance of staying under.

Latest betting odds

We have sourced the best college football odds in America for this game, which are listed here:

• Spread: Charleston Southern +42.5 (-108) / Clemson -42.5 (-108)
• Moneyline: Charleston Southern , Clemson

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Moneyline: Under @ -112 via FanDuel

According to our best college football bets, the top play to make on this game is under 54.5 points.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football action between Clemson and Charleston Southern at Memorial Stadium is scheduled to begin at 12:00 PM ET.

• Who: Charleston Southern vs. Clemson
• Date: Saturday, October 17, 2026
• Time: 12:00 PM ET/9:00AM PT
• Venue: Memorial Stadium

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Conclusion

We predict Clemson, with a 99.7% win probability, will likely beat Charleston Southern in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.