La Salle vs. Villanova prediction, odds, pick for Nov. 10, 2026

Villanova is favored to beat La Salle at The William B. Finneran Pavilion on Tuesday (7:00 PM ET), according to Dimers' men's college basketball model.

Our La Salle vs. Villanova prediction gives the Explorers a 96.0% chance of winning, but the latest odds suggest there's betting value on La Salle to cover at +22.5.

La Salle vs. Villanova key predictions

• Predicted score: Villanova 88-66 La Salle
• Villanova win probability: 96.0%
• La Salle win probability: 4.0%
• La Salle +22.5 spread: 52.0% cover probability
• Under 156.5 points: 53.1% probability

Our men's college basketball predictions project each team's final score using offensive and defensive efficiency, recent performance, long-term trends, and matchup-specific factors.

We calculate win, spread, and total probabilities based on these projections and historical CBB scoring patterns, then compare them with the latest odds to find betting value.

La Salle vs. Villanova odds

Here are the best available odds across the moneyline, spread, and total points markets we track.

• La Salle moneyline: +2400 (FanDuel)
• Villanova moneyline: -10000 (BetMGM)
• La Salle +22.5: -105 (BetMGM)
• Villanova -22.5: -105 (FanDuel)
• Over 156.5 points: -110 (Caesars Sportsbook)
• Under 156.5 points: -110 (Caesars Sportsbook)

Odds are subject to change and may vary by location.

La Salle vs. Villanova pick: La Salle +22.5 (-105)

Our model makes Villanova the likelier winner, but our best value bet is Villanova to cover the +22.5 spread at -105 on BetMGM.

Those odds give La Salle an implied cover probability of 51.2%, while our model puts it at 52.0%.

That's a 0.8% edge, the largest across the moneyline, spread, and total points markets for this game.

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La Salle vs. Villanova game details

• Matchup: La Salle Explorers vs. Villanova
• Date: Tuesday, November 10, 2026
• Time: 7:00 PM ET
• Venue: The William B. Finneran Pavilion
• Tournament details: 2026 NBA Cup

About this prediction

This preview uses predictions from our men's college basketball models, presented through a template written by our editorial team. Matchup details fill in automatically.

Predictions are estimates, not guarantees, and can change as new information comes in, such as injury news or lineup changes. Learn how our predictions work.

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