Reds vs. Guardians Prediction, Picks and Odds

Our detailed prediction and analysis for the Reds vs. Guardians MLB game on May 16, 2026 is featured below. Drawing from 10,000 game simulations, we provide expert picks, betting odds, and insights.
Start your FREE 3-day trial of Dimers Pro
FINAL
MLB
Add this game to My Favorites
FINAL
Add this game to My Favorites
MLB sport icon
MLB
Reds
4
7
May 16, 10:10PM Progressive Field
Guardians
May 16, 10:10PM Progressive Field
In-Play ProbabilitiesIn-Play
Game PredictionsPre-Game
Bets
1 2 3 4 5 6 7 8 9 RHE
Reds
0 0 1 0 3 0 0 0 0 4 5 1
Guardians
0 2 0 0 0 2 2 1 X 7 10 0
Live Probabilities
Moneyline
Over / Under
Run Line
Reds CIN
Win %
0%
100%
Guardians CLE
Win Probability
Baseball infield diamond diagram
Last At Bat
Outs
Nathaniel Lowe lines out to deep left field to Steven Kwan.
Quick Box Score
Hitting
Pitching
Reds Hitting
No.PlayerPosABRHRBIHRBBSOAVGOPS
1 D. Myers CF4111102.2501.250
2 E. De La Cruz SS3110011.3330.833
3 S. Stewart 1B2001021.0000.500
4 S. Steer LF4012000.2500.750
5 J. Bleday DH4000001.0000.000
6 M. McLain 2B4000002.0000.000
7 W. Benson PH1000001.0000.000
8 T. Stephenson C1000010.0000.500
9 N. Lowe PH1000000.0000.000
Guardians Hitting
No.PlayerPosABRHRBIHRBBSOAVGOPS
1 P. Halpin CF1000001.0000.000
2 J. Ramírez 3B4120000.5001.100
3 C. DeLauter DH4000010.0000.200
4 K. Manzardo 1B5120002.4000.800
5 T. Bazzana 2B5010003.2000.400
6 S. Kwan LF3210021.3330.933
7 A. Martínez RF4322100.5002.100
8 A. Hedges C2000021.0000.500
9 B. Rocchio SS3022010.6671.417

Featured offers

Swipe iconSwipe across to view more offers
logo
RECOMMENDED
Deposit $20, Get $50 in Trading Bonus!
T&Cs apply.
How to claim
logo
FEATURED
New DraftKings Customers: Bet $5, Get $200 in Bonus Bets Instantly
T&Cs apply.
How to claim
logo
RECOMMENDED
Double Your Winnings on your Next 10 Wagers. Up to $25 Max Bet Per Boost
T&Cs apply.
How to claim
logo
NEW PLAYERS
Bet $5, Get $150 in Bonus Bets if your bet wins!
T&Cs apply.
How to claim
logo
LIMITED-TIME
Register with code DIMERS150 to unlock $150 in bonus bets by winning your first $10 bet
T&Cs apply.
How to claim
logo
NEW PLAYERS
Get $350 in Bonus Bets Guaranteed - When You Bet $5 for 7 Days!
T&Cs apply.
How to claim
logo
RECOMMENDED
Use Code DIMERS to Get up to $100 in Bonuses by Trading in Your First 7 Days!
T&Cs apply.
How to claim
logo
TRENDING
Bet $10 Get $365 Win or Lose
T&Cs apply.
How to claim
logo
NEW PLAYERS
Get Up To $250 Back in Bonus Bets If Your First Bet Loses
T&Cs apply.
How to claim

Reds vs. Guardians: Detailed Breakdown

Matchup Overview

  • Teams: Reds vs. Guardians
  • Date: Saturday, May 16, 2026
  • Time: 6:10 PM ET
  • Venue: Progressive Field

Current Betting Odds

  • Spread: Guardians favored at -1.5
  • Total (Over/Under): 8.5
  • Moneyline Odds: Reds +141, Guardians -141

Dimers' Win Probabilities

  • Reds: 40%
  • Guardians: 60%

Dimers' predictive model, renowned for its accuracy, assesses each team's chances by simulating the outcome of the game 10,000 times. This method provides a precise and unbiased view.

Our Prediction: Who Wins?

After extensive simulations, our model gives the Reds a win probability of 40%, while the Guardians have a win probability of 60%. Discover the best spread, over/under, and moneyline odds for the game on this page.

Summary

According to our analysis, the Guardians are more likely to beat the Reds in the MLB game at Progressive Field on Saturday. Discover the best spread, over/under and moneyline odds, picks and probabilities for the game on this page.

Our Reds vs. Guardians predictions, based on sophisticated simulations and current data, guide you in making informed decisions. Remember to bet responsibly and within your financial limits.

For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

When you click or tap on a link on Dimers that goes to a third-party website that we have a commercial relationship with (such as a sportsbook), we may receive a referral fee.

For further insights, explore our expert MLB predictions and the best MLB bets today, while our in-depth analysis includes MLB props, MLB futures, MLB odds, and the latest MLB news.