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Phillies vs. Cubs Prediction, Picks and Odds

Our detailed prediction and analysis for the Phillies vs. Cubs MLB game on April 22, 2026 is featured below. Drawing from 10,000 game simulations, we provide expert picks, betting odds, and insights.
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Phillies
vs.
Apr 22, 11:40PM Wrigley Field
Cubs
Apr 22, 11:40PM Wrigley Field
Game PredictionsPre-Game
Dimers Pro Best Bets
Pre-Game Probabilities Last Updated: 2:29PM, Apr 22
Moneyline
Over / Under
Run Line
Phillies PHI
Moneyline
Win %
41%
59%
Cubs CHC
Kyle Backhus 0-0, 5.40 ERA
Matthew Boyd 1-1, 6.75 ERA
Weather Forecast
Last Updated: Apr 22, 11:02AM
Patchy rain nearby weather icon
58°FPatchy rain nearby
RoofNone
Humidity75%
Wind speed3mph
Cloud cover89%
Dew point49°F
Wind directionSE

Game Prediction Article

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Phillies vs. Cubs: Detailed Breakdown

Matchup Overview

  • Teams: Phillies vs. Cubs
  • Date: Wednesday, April 22, 2026
  • Time: 7:40 PM ET
  • Venue: Wrigley Field

Current Betting Odds

  • Spread: Cubs favored at -1.5
  • Total (Over/Under): 7.5
  • Moneyline Odds: Phillies +153, Cubs -156

Dimers' Win Probabilities

  • Phillies: 41%
  • Cubs: 59%

Dimers' predictive model, renowned for its accuracy, assesses each team's chances by simulating the outcome of the game 10,000 times. This method provides a precise and unbiased view.

Our Prediction: Who Wins?

After extensive simulations, our model gives the Phillies a win probability of 41%, while the Cubs have a win probability of 59%. Discover the best spread, over/under, and moneyline odds for the game on this page.

Summary

According to our analysis, the Cubs are more likely to beat the Phillies in the MLB game at Wrigley Field on Wednesday. Discover the best spread, over/under and moneyline odds, picks and probabilities for the game on this page.

Our Phillies vs. Cubs predictions, based on sophisticated simulations and current data, guide you in making informed decisions. Remember to bet responsibly and within your financial limits.

For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

When you click or tap on a link on Dimers that goes to a third-party website that we have a commercial relationship with (such as a sportsbook), we may receive a referral fee.

For further insights, explore our expert MLB predictions and the best MLB bets today, while our in-depth analysis includes MLB props, MLB futures, MLB odds, and the latest MLB news.

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