Yankees vs. Red Sox Prediction, Picks and Odds

Our detailed prediction and analysis for the Yankees vs. Red Sox MLB game on April 21, 2026 is featured below. Drawing from 10,000 game simulations, we provide expert picks, betting odds, and insights.
Start your FREE 3-Day trial of Dimers Pro
FINAL
MLB
Add this game to My Favorites
FINAL
Add this game to My Favorites
MLB sport icon
MLB
Yankees
4
0
Apr 21, 10:45PM Fenway Park
Red Sox
Apr 21, 10:45PM Fenway Park
In-Play ProbabilitiesIn-Play
Game PredictionsPre-Game
Bets
1 2 3 4 5 6 7 8 9 RHE
Yankees
0 1 0 0 0 2 0 1 0 4 10 0
Red Sox
0 0 0 0 0 0 0 0 0 0 4 0
Live Probabilities
Moneyline
Over / Under
Run Line
Yankees NYY
Win %
100%
0%
Red Sox BOS
Win Probability
Baseball infield diamond diagram
Last At Bat
Outs
Jarren Duran strikes out swinging.
Quick Box Score
Hitting
Pitching
Yankees Hitting
No.PlayerPosABRHRBIHRBBSOAVGOPS
1 R. McMahon 3B1000001.0000.000
2 A. Judge RF3110020.3330.933
3 B. Rice 1B4000004.0000.200
4 G. Stanton DH4123101.5002.000
5 C. Bellinger LF3110010.3330.833
6 T. Grisham CF0000000.0000.000
7 J. Chisholm 2B4020001.5001.000
8 J. Caballero SS4010002.2500.500
9 A. Wells C4010000.2500.500
Red Sox Hitting
No.PlayerPosABRHRBIHRBBSOAVGOPS
1 R. Anthony LF3000011.0000.250
2 W. Contreras 1B4010000.2500.500
3 M. Yoshida DH4000000.0000.000
4 W. Abreu RF4000000.0000.000
5 T. Story SS3000010.0000.250
6 C. Rafaela CF3010010.3330.833
7 J. Duran PH1000001.0000.000
8 C. Durbin 3B3000002.0000.000
9 C. Narváez C3010000.3330.666

Featured offers

Swipe iconSwipe across to view more offers
logo
FEATURED
New DraftKings Customers: Bet $5, Get $200 in Bonus Bets Instantly
T&Cs apply.
How to claim
logo
RECOMMENDED
Double Your Winnings on your Next 10 Wagers. Up to $25 Max Bet Per Boost
T&Cs apply.
How to claim
logo
NEW PLAYERS
Bet $5, Get $150 in Bonus Bets if your bet wins!
T&Cs apply.
How to claim
logo
RECOMMENDED
Deposit $20, Get $50 in Trading Bonus!
T&Cs apply.
How to claim
logo
LIMITED-TIME
Register with code DIMERS150 to unlock $150 in bonus bets by winning your first $10 bet
T&Cs apply.
How to claim
logo
NEW PLAYERS
Get $350 in Bonus Bets Guaranteed - When You Bet $5 for 7 Days!
T&Cs apply.
How to claim
logo
RECOMMENDED
Use Code DIMERS to Get up to $100 in Bonuses by Trading in Your First 7 Days!
T&Cs apply.
How to claim
logo
TRENDING
Bet $10 Get $365 Win or Lose
T&Cs apply.
How to claim
logo
NEW PLAYERS
Get Up To $250 Back in Bonus Bets If Your First Bet Loses
T&Cs apply.
How to claim

Yankees vs. Red Sox: Detailed Breakdown

Matchup Overview

  • Teams: Yankees vs. Red Sox
  • Date: Tuesday, April 21, 2026
  • Time: 6:45 PM ET
  • Venue: Fenway Park

Current Betting Odds

  • Spread: Red Sox favored at -1.5
  • Total (Over/Under): 8.5
  • Moneyline Odds: Yankees +116, Red Sox -115

Dimers' Win Probabilities

  • Yankees: 45%
  • Red Sox: 55%

Dimers' predictive model, renowned for its accuracy, assesses each team's chances by simulating the outcome of the game 10,000 times. This method provides a precise and unbiased view.

Our Prediction: Who Wins?

After extensive simulations, our model gives the Yankees a win probability of 45%, while the Red Sox have a win probability of 55%. Discover the best spread, over/under, and moneyline odds for the game on this page.

Summary

According to our analysis, the Red Sox are more likely to beat the Yankees in the MLB game at Fenway Park on Tuesday. Discover the best spread, over/under and moneyline odds, picks and probabilities for the game on this page.

Our Yankees vs. Red Sox predictions, based on sophisticated simulations and current data, guide you in making informed decisions. Remember to bet responsibly and within your financial limits.

For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

When you click or tap on a link on Dimers that goes to a third-party website that we have a commercial relationship with (such as a sportsbook), we may receive a referral fee.

For further insights, explore our expert MLB predictions and the best MLB bets today, while our in-depth analysis includes MLB props, MLB futures, MLB odds, and the latest MLB news.