Villanova vs. Notre Dame women's prediction, odds, pick for Nov. 1, 2026

Notre Dame is favored to beat Villanova at Palazzo dello Sport on Sunday (12:00 PM ET), according to Dimers' women's basketball model.

Our Villanova vs. Notre Dame women's prediction gives Notre Dame a 78.3% chance of winning, and the latest odds suggest there's betting value on Notre Dame to cover at -8.5, too.

Sunday's game closes the inaugural Eternal City Tip-Off doubleheader in Rome, Italy, after the Villanova and Notre Dame men's teams meet earlier that day. The event was inspired by the election of Pope Leo XIV, the first American-born pope and a Villanova alum. Our Villanova vs. Notre Dame men's prediction breaks down that matchup.

Villanova vs. Notre Dame women's key predictions

• Predicted score: Notre Dame 73-63 Villanova
• Notre Dame win probability: 78.3%
• Villanova win probability: 21.7%
• Notre Dame -8.5 spread: 55.1% cover probability
• Under 143.5 points: 54.8% probability

Our women's basketball predictions start with projected final scores for both teams, based on each team's recent and long-term efficiency at both ends of the floor, adjusted for the matchup.

We pair those projections with historical scoring trends to calculate win, spread, and total probabilities, then compare them with current odds to find betting value.

Villanova vs. Notre Dame women's odds

Here are the best available odds across the moneyline, spread, and total points markets we track.

• Villanova moneyline: +340 (BetRivers)
• Notre Dame moneyline: -380 (FanDuel)
• Villanova +8.5: -125 (FanDuel)
• Notre Dame -8.5: -106 (FanDuel)
• Over 143.5 points: -112 (FanDuel)
• Under 143.5 points: -114 (BetRivers)

Odds are subject to change and may vary by location.

Villanova vs. Notre Dame women's pick: Notre Dame -8.5 (-106)

Our model makes Notre Dame the likelier winner, and our best value bet is Notre Dame to cover the -8.5 spread at -106 on FanDuel, too.

Those odds give Notre Dame an implied cover probability of 51.5%, while our model puts it at 55.1%.

That's a 3.7% edge (accounting for rounding), the largest across the moneyline, spread, and total points markets for this game.

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Villanova vs. Notre Dame women's game details

• Matchup: Villanova vs. Notre Dame
• Date: Sunday, November 1, 2026
• Time: 12:00 PM ET
• Venue: Palazzo dello Sport

About this prediction

This preview uses predictions from our women's basketball models, presented through a template written by our editorial team. Matchup details fill in automatically.

Predictions are estimates, not guarantees, and can change as new information comes in, such as injury news or lineup changes. Learn how our predictions work.

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