Karen Khachanov vs. Alexander Blockx prediction, odds, picks for US Open 2026

Karen Khachanov will face Alexander Blockx in the quarterfinals of the US Open Men's Singles 2026 on Wednesday.

Dimers' proven tennis model projects Karen Khachanov as the most likely winner in this Khachanov vs. Blockx prediction.

This article offers a closer look at Wednesday's match, including best bets and picks.

Khachanov vs. Blockx prediction and odds

Using innovative machine learning and data, we have re-simulated the result of Wednesday's Khachanov-Blockx men's singles match, forming part of our tennis predictions coverage.

Our independent predictive model gives Khachanov a 65% chance of beating Blockx in the US Open 2026.

Additionally, Khachanov has a 62% chance of winning the first set. The simulations also show Khachanov (-2.5) has a 53% chance of covering the games spread, while the under 41.5 games has a 64% chance of hitting, according to our model.

Latest betting odds

We have researched the most up-to-date betting odds in America for this match, which are listed here:

• Moneyline: Alexander Blockx +154, Karen Khachanov -160
• First Set: Khachanov -152, Blockx +120

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Moneyline: Khachanov @ -160 via DraftKings
• First Set: Blockx @ -135 via DraftKings

According to our tennis best bets, the top play to make on this match is Karen Khachanov to win the first set.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & first serve details

The US Open 2026 match between Karen Khachanov and Alexander Blockx is scheduled to commence on Wednesday at 3:20 PM ET.

• Who: Karen Khachanov vs. Alexander Blockx
• Date: Wednesday, September 9, 2026
• Approx. Time: 3:20 PM ET/12:20PM PT
• Tournament: US Open Men's Singles 2026
• Round: Quarterfinals

All dates and times in this article are United States Eastern Time unless otherwise noted.

Conclusion

We predict Karen Khachanov, with a 65% win probability, will likely beat Alexander Blockx at the US Open 2026.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.