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Xavier vs. Butler prediction: Butler favored to win men's college basketball matchup [2/21/2026]
Get Xavier vs Butler predictions for college basketball Saturday.

Butler and Xavier will meet in men's college basketball action at Hinkle Fieldhouse on Saturday, starting at 1:30 PM ET.
Based on updated simulations, Dimers' advanced college basketball model predicts Butler as the most likely winner of the Xavier vs. Butler game.
This article offers a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks.
Xavier vs. Butler prediction: Who will win and cover?
Using innovative machine learning and statistical analysis, we have simulated the outcome of Saturday's NCAA basketball game between Xavier and Butler 10,000 times as part of our men's college basketball predictions coverage.
Our famous predictive model currently gives Butler a 62% chance of beating Xavier. Our predicted final score has Butler winning 82-78.
According to our model, Xavier (+3.5) has a 53% chance of covering the spread, while the over/under total of 159.5 points has a 51% chance of going over.
Xavier vs. Butler odds
We have sourced the best men's college basketball odds in America for this game, which are listed here:
| Bet Type | Xavier | Butler |
|---|---|---|
| Spread | +3.5 (-105) | -3.5 (-115) |
| Moneyline | +160 | -190 |
| Total | o159.5 (-110) | u159.5 (-108) |
All odds are correct at the time of publication and are subject to change.
Xavier vs. Butler picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Xavier +3.5 | -105 |
| Moneyline | Xavier | +160 |
| Total | Over 159.5 | -110 |
According to our men's college basketball best bets, the top play to make on this game is Xavier +3.5 at the spread.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Xavier vs. Butler game-day updates and essential details
Saturday's men's college basketball game between Butler and Xavier at Hinkle Fieldhouse is scheduled to begin at 1:30 PM ET.
- Who: Xavier vs. Butler
- Date: Saturday, February 21, 2026
- Time: 1:30 PM ET/10:30AM PT
- Venue: Hinkle Fieldhouse
Conclusion
We predict Butler, with a 62% win probability, will likely beat Xavier on Saturday.
AI and automation have enhanced this article to quickly deliver accurate Xavier vs. Butler insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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