Southampton vs. Manchester City Prediction, Odds, Premier League Picks [5/10/2025]

Premier League action continues on Saturday at 10:00AM ET as the favored Manchester City squares off with Southampton at St. Mary's Stadium.

Based on updated simulations, Dimers' proven Premier League model (see Dimers Pro for full access) predicts Manchester City as the most likely winner of the game.

"Our team has used the latest data to run 10,000 simulations of Saturday's Southampton-Manchester City game," said Jason Bevilacqua from Dimers.

"After incorporating the most recent updates and numerous additional inputs, our prediction gives Southampton a 10.9% chance of winning, Manchester City a 73.0% chance, and a 16.2% chance of a draw."

For a closer look at Saturday's matchup, including best bets and picks, visit our interactive Southampton vs. Manchester City predictions page.

Southampton vs. Manchester City Prediction: Who Will Win?

Using powerful machine learning and data, we have simulated the result of Saturday's Premier League match between Southampton and Manchester City 10,000 times as part of our Premier League predictions coverage.

Our famous predictive model currently indicates a 10.9% chance of Southampton winning, a 73.0% chance for Manchester City, and a 16.2% chance of a draw.

Southampton vs. Manchester City Odds

We have researched the best Premier League odds in America for this game, which are listed here:

Market	Southampton	Manchester City	Draw
Moneyline	+1300	-500	+700

All odds are correct at the time of publication and are subject to change.

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Southampton vs. Manchester City Picks and Best Bets

Our model's biggest edge in the Southampton vs. Manchester City matchup is on the moneyline.

Our expert predictions, matched against the current odds, reveal the best Premier League picks and Premier League best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Southampton vs. Manchester City: Correct Score and BTTS Predictions

Here are the top three most likely final scores according to our model, with a 2-0 Manchester City win being the most probable:

Final Score	Probability
SOU 0-2 MCI	10.9%
SOU 1-2 MCI	9.4%
SOU 0-3 MCI	9%

When it comes to the both teams to score (BTTS) market, we project a 52.8% chance that both teams scoring, and a 47.2% probability of at least one team keeping a clean sheet.

These predictions are based on each team's average score after 10,000 simulations.

Southampton vs. Manchester City Game-Day Updates and Essential Details

Saturday's Premier League action between Southampton and Manchester City at St. Mary's Stadium is scheduled to commence in the USA at 10:00AM ET.

• Who: Southampton vs. Manchester City
• Date: Saturday, May 10, 2025
• Time: 10:00AM ET/7:00AM PT
• Venue: St. Mary's Stadium

Dimers.com's in-depth preview of Saturday's Southampton vs. Manchester City matchup includes our prediction, picks and the latest betting odds.

Before making any Manchester City vs. Southampton picks, be sure to check out the latest Premier League predictions and betting advice from Dimers Pro.

Conclusion

According to our computer model, Southampton has a 10.9% win probability on Saturday, Manchester City has a 73.0% win probability, and there is a 16.2% chance that the game will end in a draw.

AI and automation have enhanced this article to quickly deliver accurate Southampton vs. Manchester City insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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